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• W3044057346 abstract "Abstract Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here we report that knocking out these three factors markedly extends survival in the SOD1 G93A ALS mouse model, providing evidence for gliosis as a potential ALS therapeutic target." @default.
• W3044057346 created "2020-07-29" @default.
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• W3044057346 date "2020-07-27" @default.
• W3044057346 modified "2023-10-18" @default.
• W3044057346 title "Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model" @default.
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• W3044057346 doi "https://doi.org/10.1038/s41467-020-17514-9" @default.
• W3044057346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385161" @default.
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