FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044091409> ?p ?o ?g. }

• W3044091409 endingPage "111044" @default.
• W3044091409 startingPage "111044" @default.
• W3044091409 abstract "Exposure to ambient fine particulate matter (PM2.5) is associated with various adverse health outcomes. Although several mechanisms have been proposed including oxidative stress and inflammatory responses, the exact mechanism is still unknown. Few studies have investigated the mechanism linking PM2.5 and blood pressure (BP). In this study, we measured urinary metabolites and BP -related renin-angiotensin-aldosterone system (RAAS) to investigate the associations between ambient PM2.5 exposure and BP in healthy C57BL/6 mice. The C57BL/6 mice were exposed to ambient concentrated PM2.5 or filtered air (FA) for 16 weeks. Systolic BP and diastolic BP were measured by noninvasive BP system. The urine metabolites were quantified using the untargeted metabolomics approach. The expression of RAAS-related proteins angiotensin-converting enzyme (ACE)2, angiotensin (Ang) II, Ang (1–7) and aldosterone (ALD) were measured using Western blot and ELISA kits. The metabolomics analysis demonstrated that PM2.5 exposure induced significant changes of some metabolites in urine, including stress hormones, amino acids, fatty acids, and lipids. Furthermore, there was an elevation of BP, increase of serous Ang II and ALD, along with the decrease of ACE2 and Ang (1–7) in kidney in the PM2.5-exposed mice compared with FA-exposed mice. The results demonstrated that PM2.5 exposure-induced BP elevation might be associated with RAAS activation. Meanwhile, PM2.5 exposure-induced changes of stress hormone and lipid metabolism might mediate the activation of RAAS. The results suggested that the systemic stress hormone and lipid metabolism was associated with the development of hypertension." @default.
• W3044091409 created "2020-07-29" @default.
• W3044091409 creator A5001580476 @default.
• W3044091409 creator A5009697908 @default.
• W3044091409 creator A5012194957 @default.
• W3044091409 creator A5013100725 @default.
• W3044091409 creator A5019047946 @default.
• W3044091409 creator A5027240571 @default.
• W3044091409 creator A5028193901 @default.
• W3044091409 creator A5044742215 @default.
• W3044091409 creator A5046362363 @default.
• W3044091409 creator A5066843127 @default.
• W3044091409 creator A5076066320 @default.
• W3044091409 creator A5077713155 @default.
• W3044091409 creator A5082142226 @default.
• W3044091409 date "2020-10-01" @default.
• W3044091409 modified "2023-09-28" @default.
• W3044091409 title "Ambient fine particulate matter induced the elevation of blood pressure through ACE2/Ang(1–7) pathway: The evidence from urine metabolites" @default.
• W3044091409 cites W1523885354 @default.
• W3044091409 cites W1574459634 @default.
• W3044091409 cites W1968508379 @default.
• W3044091409 cites W1974919829 @default.
• W3044091409 cites W2002094924 @default.
• W3044091409 cites W2008022146 @default.
• W3044091409 cites W2019402080 @default.
• W3044091409 cites W2019514289 @default.
• W3044091409 cites W2028439883 @default.
• W3044091409 cites W2038459691 @default.
• W3044091409 cites W2054112982 @default.
• W3044091409 cites W2063028213 @default.
• W3044091409 cites W2079242849 @default.
• W3044091409 cites W2110289049 @default.
• W3044091409 cites W2112241886 @default.
• W3044091409 cites W2114614037 @default.
• W3044091409 cites W2123510374 @default.
• W3044091409 cites W2138998720 @default.
• W3044091409 cites W2150751323 @default.
• W3044091409 cites W2159692800 @default.
• W3044091409 cites W2171207287 @default.
• W3044091409 cites W2301389244 @default.
• W3044091409 cites W2307715944 @default.
• W3044091409 cites W2312836440 @default.
• W3044091409 cites W2328709075 @default.
• W3044091409 cites W2337855427 @default.
• W3044091409 cites W2408231795 @default.
• W3044091409 cites W2466716896 @default.
• W3044091409 cites W2545087561 @default.
• W3044091409 cites W2593910489 @default.
• W3044091409 cites W2617655798 @default.
• W3044091409 cites W2618061614 @default.
• W3044091409 cites W2727933315 @default.
• W3044091409 cites W2739223225 @default.
• W3044091409 cites W2746051823 @default.
• W3044091409 cites W2752312135 @default.
• W3044091409 cites W2753813400 @default.
• W3044091409 cites W2760126017 @default.
• W3044091409 cites W2761837436 @default.
• W3044091409 cites W2767272909 @default.
• W3044091409 cites W2788694370 @default.
• W3044091409 cites W2789378055 @default.
• W3044091409 cites W2792031545 @default.
• W3044091409 cites W2811408230 @default.
• W3044091409 cites W2893184798 @default.
• W3044091409 cites W2894901593 @default.
• W3044091409 cites W2898149752 @default.
• W3044091409 cites W2901772672 @default.
• W3044091409 cites W2910716440 @default.
• W3044091409 cites W2911435913 @default.
• W3044091409 cites W2918156958 @default.
• W3044091409 doi "https://doi.org/10.1016/j.ecoenv.2020.111044" @default.
• W3044091409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32888613" @default.
• W3044091409 hasPublicationYear "2020" @default.
• W3044091409 type Work @default.
• W3044091409 sameAs 3044091409 @default.
• W3044091409 citedByCount "10" @default.
• W3044091409 countsByYear W30440914092021 @default.
• W3044091409 countsByYear W30440914092022 @default.
• W3044091409 countsByYear W30440914092023 @default.
• W3044091409 crossrefType "journal-article" @default.
• W3044091409 hasAuthorship W3044091409A5001580476 @default.
• W3044091409 hasAuthorship W3044091409A5009697908 @default.
• W3044091409 hasAuthorship W3044091409A5012194957 @default.
• W3044091409 hasAuthorship W3044091409A5013100725 @default.
• W3044091409 hasAuthorship W3044091409A5019047946 @default.
• W3044091409 hasAuthorship W3044091409A5027240571 @default.
• W3044091409 hasAuthorship W3044091409A5028193901 @default.
• W3044091409 hasAuthorship W3044091409A5044742215 @default.
• W3044091409 hasAuthorship W3044091409A5046362363 @default.
• W3044091409 hasAuthorship W3044091409A5066843127 @default.
• W3044091409 hasAuthorship W3044091409A5076066320 @default.
• W3044091409 hasAuthorship W3044091409A5077713155 @default.
• W3044091409 hasAuthorship W3044091409A5082142226 @default.
• W3044091409 hasConcept C126322002 @default.
• W3044091409 hasConcept C134018914 @default.
• W3044091409 hasConcept C185592680 @default.
• W3044091409 hasConcept C198710026 @default.
• W3044091409 hasConcept C2776151105 @default.
• W3044091409 hasConcept C2778525890 @default.

• next