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• W3044114345 endingPage "108251" @default.
• W3044114345 startingPage "108251" @default.
• W3044114345 abstract "It is a grand challenge to develop a truly effective treatment of substance use disorder (SUD), particularly for cocaine and other drugs without an FDA-approved treatment available, because a truly effective therapy must effectively block the drug's physiological and reinforcing effects during the entire period of treatment in order to achieve the long-time abstinence required by the FDA. Whether a biologic, such as monoclonal antibody, vaccine, or therapeutic enzyme, can be truly effective for SUD treatment or not has been the subject of extensive debate. The main debate question is whether a biologic, particularly an exogenous enzyme, can effectively block the drug's reinforcing effect. In this report, we demonstrate that a modest dose of a recently redesigned long-acting cocaine hydrolase, CocH3-Fc(M6), can be used to effectively block the psychostimulant, discriminative stimulus, and reinforcing effects of cocaine for a sufficiently long period of time. For example, a dose of 3 mg/kg CocH3-Fc(M6) completely blocked the discriminative stimulus and reinforcing effects for 24/25 days and continued to significantly attenuate/decrease the cocaine effects for at least 29 days in rats. All the animal data consistently suggest that the long-acting cocaine hydrolase is a truly promising candidate of enzyme therapy for treatment of cocaine use disorder." @default.
• W3044114345 created "2020-07-29" @default.
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• W3044114345 date "2020-10-01" @default.
• W3044114345 modified "2023-10-01" @default.
• W3044114345 title "Clinical potential of a rationally engineered enzyme for treatment of cocaine dependence: Long-lasting blocking of the psychostimulant, discriminative stimulus, and reinforcing effects of cocaine" @default.
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• W3044114345 doi "https://doi.org/10.1016/j.neuropharm.2020.108251" @default.
• W3044114345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7530019" @default.
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• W3044114345 hasPublicationYear "2020" @default.
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