FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044166856> ?p ?o ?g. }

• W3044166856 endingPage "1075" @default.
• W3044166856 startingPage "1068" @default.
• W3044166856 abstract "BACKGROUND Hemorrhagic shock (HS) and trauma can result in an endotheliopathy of trauma, characterized by endothelial compromise, inflammation, and aberrant coagulation. Kcentra, a prothrombin concentrate, has been demonstrated to mitigate pulmonary vascular leak in a murine model of HS. We investigated the effects of Kcentra in a rat model of HS, to achieve physiologic endpoints of relevance. METHODS Rats subjected to a grade intravenous splenic injury and controlled hemorrhage for 60 minutes were resuscitated with shed volumes of (1) Lactated Ringer’s (LR) solution, (2) LR + 20 IU/kg Kcentra, (3) LR + 50 IU/kg Kcentra, (4) rat fresh frozen plasma (RFFP), or (5) human fresh frozen plasma (HFFP). Blood was harvested for monitoring metabolic and coagulation function. Rat lungs were evaluated for lung injury and permeability. RESULTS Animals resuscitated with LR displayed a significant increase in pulmonary vascular permeability (sham, 407.9 ± 122.4; shock + LR, 2040 ± 1462). Resuscitation with RFFP (606.5 ± 169.3) reduced leak; however, treatment with Kcentra (HS + Kcentra [20 IU/kg]: 1792 ± 903.4, HS + Kcentra [50 IU/kg]: 1876 ± 1103), and HFFP (1450 ± 533.2) had no significant effect on permeability. Kcentra modestly altered clotting parameters. Metabolic measures, such as lactate, pH, and base deficit, were restored to baseline levels by both RFFP and HFFP, but not Kcentra or LR. CONCLUSION Kcentra did not alter pulmonary vascular permeability, but modestly increased clotting potential in injured rats. This suggests that there may be a xenogenic reaction of human products in rats and that the effects of Kcentra on vascular stability may be distinct from its ability to modulate clotting. Our data indicate that the species chosen and utilized for in vivo preclinical testing of human derived blood products is of critical importance in determining their efficacy in animal models and is the primary impetus to communicate these results." @default.
• W3044166856 created "2020-07-29" @default.
• W3044166856 creator A5014438120 @default.
• W3044166856 creator A5020051684 @default.
• W3044166856 creator A5024576216 @default.
• W3044166856 creator A5032889377 @default.
• W3044166856 creator A5039919313 @default.
• W3044166856 creator A5052403695 @default.
• W3044166856 creator A5068434667 @default.
• W3044166856 creator A5073839964 @default.
• W3044166856 creator A5081584870 @default.
• W3044166856 date "2020-07-16" @default.
• W3044166856 modified "2023-09-27" @default.
• W3044166856 title "The effects of human prothrombin complex concentrate on hemorrhagic shock-induced lung injury in rats: Implications for testing human blood products in rodents" @default.
• W3044166856 cites W1990482498 @default.
• W3044166856 cites W2006006000 @default.
• W3044166856 cites W2016051325 @default.
• W3044166856 cites W2021953458 @default.
• W3044166856 cites W2024808820 @default.
• W3044166856 cites W2056002693 @default.
• W3044166856 cites W2077464683 @default.
• W3044166856 cites W2084168315 @default.
• W3044166856 cites W2094857616 @default.
• W3044166856 cites W2119063100 @default.
• W3044166856 cites W2126420535 @default.
• W3044166856 cites W2128719413 @default.
• W3044166856 cites W2133226878 @default.
• W3044166856 cites W2133336368 @default.
• W3044166856 cites W2171385717 @default.
• W3044166856 cites W2323678124 @default.
• W3044166856 cites W2332249743 @default.
• W3044166856 cites W2334967623 @default.
• W3044166856 cites W2404062050 @default.
• W3044166856 cites W2412233937 @default.
• W3044166856 cites W2460769526 @default.
• W3044166856 cites W2508162150 @default.
• W3044166856 cites W2660079355 @default.
• W3044166856 cites W2780275772 @default.
• W3044166856 cites W2794041158 @default.
• W3044166856 cites W2807655233 @default.
• W3044166856 cites W2899810194 @default.
• W3044166856 cites W2932976565 @default.
• W3044166856 cites W2938028646 @default.
• W3044166856 cites W3020992950 @default.
• W3044166856 doi "https://doi.org/10.1097/ta.0000000000002890" @default.
• W3044166856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32697449" @default.
• W3044166856 hasPublicationYear "2020" @default.
• W3044166856 type Work @default.
• W3044166856 sameAs 3044166856 @default.
• W3044166856 citedByCount "4" @default.
• W3044166856 countsByYear W30441668562021 @default.
• W3044166856 countsByYear W30441668562022 @default.
• W3044166856 crossrefType "journal-article" @default.
• W3044166856 hasAuthorship W3044166856A5014438120 @default.
• W3044166856 hasAuthorship W3044166856A5020051684 @default.
• W3044166856 hasAuthorship W3044166856A5024576216 @default.
• W3044166856 hasAuthorship W3044166856A5032889377 @default.
• W3044166856 hasAuthorship W3044166856A5039919313 @default.
• W3044166856 hasAuthorship W3044166856A5052403695 @default.
• W3044166856 hasAuthorship W3044166856A5068434667 @default.
• W3044166856 hasAuthorship W3044166856A5073839964 @default.
• W3044166856 hasAuthorship W3044166856A5081584870 @default.
• W3044166856 hasConcept C113045295 @default.
• W3044166856 hasConcept C126322002 @default.
• W3044166856 hasConcept C2777714996 @default.
• W3044166856 hasConcept C2778165595 @default.
• W3044166856 hasConcept C2778382381 @default.
• W3044166856 hasConcept C2781300812 @default.
• W3044166856 hasConcept C2993366118 @default.
• W3044166856 hasConcept C42219234 @default.
• W3044166856 hasConcept C66112548 @default.
• W3044166856 hasConcept C71924100 @default.
• W3044166856 hasConcept C77171857 @default.
• W3044166856 hasConcept C89560881 @default.
• W3044166856 hasConceptScore W3044166856C113045295 @default.
• W3044166856 hasConceptScore W3044166856C126322002 @default.
• W3044166856 hasConceptScore W3044166856C2777714996 @default.
• W3044166856 hasConceptScore W3044166856C2778165595 @default.
• W3044166856 hasConceptScore W3044166856C2778382381 @default.
• W3044166856 hasConceptScore W3044166856C2781300812 @default.
• W3044166856 hasConceptScore W3044166856C2993366118 @default.
• W3044166856 hasConceptScore W3044166856C42219234 @default.
• W3044166856 hasConceptScore W3044166856C66112548 @default.
• W3044166856 hasConceptScore W3044166856C71924100 @default.
• W3044166856 hasConceptScore W3044166856C77171857 @default.
• W3044166856 hasConceptScore W3044166856C89560881 @default.
• W3044166856 hasIssue "6" @default.
• W3044166856 hasLocation W30441668561 @default.
• W3044166856 hasOpenAccess W3044166856 @default.
• W3044166856 hasPrimaryLocation W30441668561 @default.
• W3044166856 hasRelatedWork W108741674 @default.
• W3044166856 hasRelatedWork W2015383962 @default.
• W3044166856 hasRelatedWork W2022854759 @default.
• W3044166856 hasRelatedWork W2192079399 @default.
• W3044166856 hasRelatedWork W2356176335 @default.
• W3044166856 hasRelatedWork W2374120434 @default.
• W3044166856 hasRelatedWork W2461928637 @default.
• W3044166856 hasRelatedWork W3044166856 @default.

• next