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- W3044171569 endingPage "6509" @default.
- W3044171569 startingPage "6493" @default.
- W3044171569 abstract "Lung cancer is currently the malignant tumor with the highest incidence and mortality in the world, while non-small cell lung cancer (NSCLC) is the most common pathological type of lung caner. In the past few decades, the only treatment options available for advanced NSCLC patients have been targeted therapy or chemotherapy, but these therapies are inevitably tolerated by tumors. The discovery of immune checkpints that mediate the immune escape of tumor cells have been promoting a series of immune checkpoint inhibitors to be used in cancer treatment and achieved great results. Among them, pembrolizumab is currently the only PD-1 inhibitor approved for first-line treatment of NSCLC, whether it is monotherapy or combination therapy, for creditable performance in KEYNOTE studies. In this review, we systematically integrate the latest series of clinical trial results, pharmacological mechanisms, adverse events (AEs) and predictive biomarkers in the first-line treatment of NSCLC. We hope pembrolizumab could become a better choice for more clinicians and benefit more patients with advanced NSCLC." @default.
- W3044171569 created "2020-07-29" @default.
- W3044171569 creator A5004133329 @default.
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- W3044171569 creator A5056967606 @default.
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- W3044171569 creator A5090589774 @default.
- W3044171569 date "2020-07-01" @default.
- W3044171569 modified "2023-10-16" @default.
- W3044171569 title "<p>A Review About Pembrolizumab in First-Line Treatment of Advanced NSCLC: Focus on KEYNOTE Studies</p>" @default.
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