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• W3044179954 abstract "Abstract Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer. We developed a novel vaccine platform based on a unique three-plasmid system to efficiently generate recombinant MVA vectors from chemically synthesized DNA. In response to the ongoing global pandemic caused by SARS coronavirus-2 (SARS-CoV-2), we used this novel vaccine platform to rapidly produce fully synthetic MVA (sMVA) vectors co-expressing SARS-CoV-2 spike and nucleocapsid antigens, two immunodominant antigens implicated in protective immunity. Mice immunized with these sMVA vectors developed robust SARS-CoV-2 antigen-specific humoral and cellular immune responses, including potent neutralizing antibodies. These results demonstrate the potential of a novel vaccine platform based on synthetic DNA to efficiently generate recombinant MVA vectors and to rapidly develop a multi-antigenic poxvirus-based SARS-CoV-2 vaccine candidate." @default.
• W3044179954 created "2020-07-29" @default.
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• W3044179954 date "2020-07-17" @default.
• W3044179954 modified "2023-10-07" @default.
• W3044179954 title "Development of a Multi-Antigenic SARS-CoV-2 Vaccine Using a Synthetic Poxvirus Platform" @default.
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• W3044179954 doi "https://doi.org/10.21203/rs.3.rs-40198/v1" @default.
• W3044179954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7373143" @default.
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• W3044179954 hasPublicationYear "2020" @default.
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