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• W3044196334 startingPage "650" @default.
• W3044196334 abstract "Alzheimer’s disease is a chronic and irreversible pathological process that has become the most prevalent neurodegenerative disease. Currently, it is considered a multifactorial disease where oxidative stress and chronic neuroinflammation play a crucial role in its onset and development. Its characteristic neuronal loss has been related to the formation of neurofibrillary tangles mainly composed by hyperphosphorylated tau protein. Hyperphosphorylation of tau protein is related to the over-activity of GSK-3β, a kinase that participates in several pathological mechanisms including neuroinflammation. Neuronal loss is also related to cytosolic Ca2+ homeostasis dysregulation that triggers apoptosis and free radicals production, contributing to oxidative damage and, finally, neuronal death. Under these premises, we have obtained a new family of 4,7-dihydro-2H-pyrazolo[3–b]pyridines as multitarget directed ligands showing potent antioxidant properties and able to scavenge both oxygen and nitrogen radical species, and also, with anti-inflammatory properties. Further characterization has demonstrated their capacity to inhibit GSK-3β and to block L-type voltage dependent calcium channels. Novel derivatives have also demonstrated an interesting neuroprotective profile on in vitro models of neurodegeneration. Finally, compound 4g revokes cellular death induced by tau hyperphosphorylation in hippocampal slices by blocking reactive oxygen species (ROS) production. In conclusion, the multitarget profile exhibited by these compounds is a novel therapeutic strategy of potential interest in the search of novel treatments for Alzheimer’s disease." @default.
• W3044196334 created "2020-07-29" @default.
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• W3044196334 date "2020-07-22" @default.
• W3044196334 modified "2023-10-14" @default.
• W3044196334 title "Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer’s Disease" @default.
• W3044196334 cites W1510439895 @default.
• W3044196334 cites W1528908480 @default.
• W3044196334 cites W1532873251 @default.
• W3044196334 cites W1577837690 @default.
• W3044196334 cites W1629179716 @default.
• W3044196334 cites W1697463694 @default.
• W3044196334 cites W1965138613 @default.
• W3044196334 cites W1968858083 @default.
• W3044196334 cites W1971757965 @default.
• W3044196334 cites W1975514925 @default.
• W3044196334 cites W1978293942 @default.
• W3044196334 cites W1982947429 @default.
• W3044196334 cites W1989036097 @default.
• W3044196334 cites W1990350348 @default.
• W3044196334 cites W1994184185 @default.
• W3044196334 cites W1996944110 @default.
• W3044196334 cites W1998088595 @default.
• W3044196334 cites W1999148207 @default.
• W3044196334 cites W2010412878 @default.
• W3044196334 cites W2011132528 @default.
• W3044196334 cites W2013144126 @default.
• W3044196334 cites W2021460489 @default.
• W3044196334 cites W2022009786 @default.
• W3044196334 cites W2022865784 @default.
• W3044196334 cites W2024121244 @default.
• W3044196334 cites W2025313184 @default.
• W3044196334 cites W2025804381 @default.
• W3044196334 cites W2026976753 @default.
• W3044196334 cites W2028320880 @default.
• W3044196334 cites W2032643430 @default.
• W3044196334 cites W2037174252 @default.
• W3044196334 cites W2042935838 @default.
• W3044196334 cites W2045772297 @default.
• W3044196334 cites W2067656585 @default.
• W3044196334 cites W2073533877 @default.
• W3044196334 cites W2074631079 @default.
• W3044196334 cites W2074840951 @default.
• W3044196334 cites W2079286959 @default.
• W3044196334 cites W2082400315 @default.
• W3044196334 cites W2082429191 @default.
• W3044196334 cites W2093979148 @default.
• W3044196334 cites W2096045337 @default.
• W3044196334 cites W2096158347 @default.
• W3044196334 cites W2097398649 @default.
• W3044196334 cites W2103024032 @default.
• W3044196334 cites W2103163836 @default.
• W3044196334 cites W2104194752 @default.
• W3044196334 cites W2117223537 @default.
• W3044196334 cites W2117433535 @default.
• W3044196334 cites W2118394016 @default.
• W3044196334 cites W2129470375 @default.
• W3044196334 cites W2134967712 @default.
• W3044196334 cites W2139119152 @default.
• W3044196334 cites W2142632286 @default.
• W3044196334 cites W2171645631 @default.
• W3044196334 cites W2223404154 @default.
• W3044196334 cites W2316132249 @default.
• W3044196334 cites W2582480647 @default.
• W3044196334 cites W2601136449 @default.
• W3044196334 cites W2605571752 @default.
• W3044196334 cites W2741648395 @default.
• W3044196334 cites W2764071986 @default.
• W3044196334 cites W2783814711 @default.
• W3044196334 cites W2792991438 @default.
• W3044196334 cites W2807826284 @default.
• W3044196334 cites W2884124308 @default.
• W3044196334 cites W2887806978 @default.
• W3044196334 cites W2911493122 @default.
• W3044196334 cites W2926611089 @default.
• W3044196334 cites W2953078378 @default.
• W3044196334 cites W2968033626 @default.
• W3044196334 cites W2995055644 @default.
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• W3044196334 doi "https://doi.org/10.3390/antiox9080650" @default.
• W3044196334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7463999" @default.
• W3044196334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32708053" @default.
• W3044196334 hasPublicationYear "2020" @default.
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