FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044202482> ?p ?o ?g. }

• W3044202482 endingPage "110" @default.
• W3044202482 startingPage "104" @default.
• W3044202482 abstract "Background: The combination of two or more therapeutic drugs is an attractive approach to improve the treatment of experimental tumors. Leveraging nanocarriers for combinational drug delivery can allow control over drug biological fate and promote co-localization in the same area of the body. However, there are certain concerns regarding the biodegradability and potential longterm toxicity arising from these synthetic nanoscale carriers. Objective: Our aim was to develop a combinational nanodrug delivery system formed by selfassembling of amphiphilic drug molecules.minimizing potential toxicities associated with using additional synthetic nanocarriers. Methods: A novel prodrug chlorambucil gemcitabine conjugate was synthesized, this prodrug was used for the encapsulation of an additional hydrophobic anticancer drug paclitaxel, taking the form of combinational nanodrugs. Particle size and zeta potential were evaluated, cytotoxicity assay and apoptosis/cell cycle analysis were also performed to validate the anticancer efficacy of the combinational nanodrugs. Results: The combinational nanodrugs were acquired by means of nanoprecipitation. In A549 lung adenocarcinoma cell line, cellular assays revealed that co-delivery of low dosage paclitaxel with chlorambucil gemcitabine conjugate can act synergistically to inhibit cell growth and induce accumulation of cells in the G2/M phase with a concomitant decrease in G0/G1 compartment. Conclusion: Chlorambucil gemcitabine conjugate and paclitaxel can co-assemble into composite nanoparticles by a nanoprecipitation process and the resulting combinational nanodrugs showed a synergistic anticancer effect. This synthetic nanocarrier-free approach might broaden the nanodrug concept and have potential in cancer therapy." @default.
• W3044202482 created "2020-07-29" @default.
• W3044202482 creator A5000337279 @default.
• W3044202482 creator A5031508846 @default.
• W3044202482 date "2021-02-26" @default.
• W3044202482 modified "2023-09-24" @default.
• W3044202482 title "A Novel Combinational Nanodrug Delivery System Induces Synergistic Inhibition of Lung Adenocarcinoma Cells In vitro" @default.
• W3044202482 cites W1607569494 @default.
• W3044202482 cites W1974956095 @default.
• W3044202482 cites W1989005337 @default.
• W3044202482 cites W2001198210 @default.
• W3044202482 cites W2003766168 @default.
• W3044202482 cites W2016969958 @default.
• W3044202482 cites W2020970511 @default.
• W3044202482 cites W2024382973 @default.
• W3044202482 cites W2056638782 @default.
• W3044202482 cites W2065941395 @default.
• W3044202482 cites W2093130371 @default.
• W3044202482 cites W2103562758 @default.
• W3044202482 cites W2127287358 @default.
• W3044202482 cites W2158558808 @default.
• W3044202482 cites W2323376599 @default.
• W3044202482 cites W2553143094 @default.
• W3044202482 cites W2602586354 @default.
• W3044202482 cites W2783255740 @default.
• W3044202482 cites W2794011199 @default.
• W3044202482 cites W2799660215 @default.
• W3044202482 cites W2891480709 @default.
• W3044202482 cites W2904389476 @default.
• W3044202482 cites W2941675001 @default.
• W3044202482 cites W2954237796 @default.
• W3044202482 cites W2954948277 @default.
• W3044202482 cites W2965949840 @default.
• W3044202482 cites W2983449541 @default.
• W3044202482 cites W2990531448 @default.
• W3044202482 cites W2991179548 @default.
• W3044202482 cites W2995530698 @default.
• W3044202482 cites W2997516063 @default.
• W3044202482 cites W3004734609 @default.
• W3044202482 doi "https://doi.org/10.2174/1570180817999200719152426" @default.
• W3044202482 hasPublicationYear "2021" @default.
• W3044202482 type Work @default.
• W3044202482 sameAs 3044202482 @default.
• W3044202482 citedByCount "3" @default.
• W3044202482 countsByYear W30442024822022 @default.
• W3044202482 countsByYear W30442024822023 @default.
• W3044202482 crossrefType "journal-article" @default.
• W3044202482 hasAuthorship W3044202482A5000337279 @default.
• W3044202482 hasAuthorship W3044202482A5031508846 @default.
• W3044202482 hasConcept C108215921 @default.
• W3044202482 hasConcept C109316439 @default.
• W3044202482 hasConcept C126511603 @default.
• W3044202482 hasConcept C134306372 @default.
• W3044202482 hasConcept C141071460 @default.
• W3044202482 hasConcept C178790620 @default.
• W3044202482 hasConcept C18150654 @default.
• W3044202482 hasConcept C185592680 @default.
• W3044202482 hasConcept C197336794 @default.
• W3044202482 hasConcept C202751555 @default.
• W3044202482 hasConcept C2776694085 @default.
• W3044202482 hasConcept C2776755627 @default.
• W3044202482 hasConcept C2777292972 @default.
• W3044202482 hasConcept C2777866208 @default.
• W3044202482 hasConcept C2779820397 @default.
• W3044202482 hasConcept C2780035454 @default.
• W3044202482 hasConcept C2780258809 @default.
• W3044202482 hasConcept C33923547 @default.
• W3044202482 hasConcept C55493867 @default.
• W3044202482 hasConcept C71924100 @default.
• W3044202482 hasConcept C98274493 @default.
• W3044202482 hasConceptScore W3044202482C108215921 @default.
• W3044202482 hasConceptScore W3044202482C109316439 @default.
• W3044202482 hasConceptScore W3044202482C126511603 @default.
• W3044202482 hasConceptScore W3044202482C134306372 @default.
• W3044202482 hasConceptScore W3044202482C141071460 @default.
• W3044202482 hasConceptScore W3044202482C178790620 @default.
• W3044202482 hasConceptScore W3044202482C18150654 @default.
• W3044202482 hasConceptScore W3044202482C185592680 @default.
• W3044202482 hasConceptScore W3044202482C197336794 @default.
• W3044202482 hasConceptScore W3044202482C202751555 @default.
• W3044202482 hasConceptScore W3044202482C2776694085 @default.
• W3044202482 hasConceptScore W3044202482C2776755627 @default.
• W3044202482 hasConceptScore W3044202482C2777292972 @default.
• W3044202482 hasConceptScore W3044202482C2777866208 @default.
• W3044202482 hasConceptScore W3044202482C2779820397 @default.
• W3044202482 hasConceptScore W3044202482C2780035454 @default.
• W3044202482 hasConceptScore W3044202482C2780258809 @default.
• W3044202482 hasConceptScore W3044202482C33923547 @default.
• W3044202482 hasConceptScore W3044202482C55493867 @default.
• W3044202482 hasConceptScore W3044202482C71924100 @default.
• W3044202482 hasConceptScore W3044202482C98274493 @default.
• W3044202482 hasFunder F4320322999 @default.
• W3044202482 hasIssue "1" @default.
• W3044202482 hasLocation W30442024821 @default.
• W3044202482 hasOpenAccess W3044202482 @default.
• W3044202482 hasPrimaryLocation W30442024821 @default.
• W3044202482 hasRelatedWork W1607569494 @default.
• W3044202482 hasRelatedWork W1912498426 @default.

• next