FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044203957> ?p ?o ?g. }

• W3044203957 endingPage "58" @default.
• W3044203957 startingPage "51" @default.
• W3044203957 abstract "A novel long-term murine model for Graves' disease (GD) using repeated, long-term immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human thyrotropin receptor (Ad-TSHR) was applied to evaluate the functional anti-TSHR-antibody (TSHR-Ab) profile.BALB/c mice received 7 immunizations with either 1010 plaque-forming units of Ad-TSHR or control Ad-GFP. Naïve (nonimmuized native) mice were also studied. Three 3-weekly immunizations were followed by 4-weekly boosts until the 7th immunization. Blocking (TBAb) and stimulating (TSAb) TSHR-Ab were measured with bioassays. Assay cut-offs for TBAb/TSAb were at 34% inhibition and a specimen-to-reference ratio (SRR) of 140%.Nineteen (8 Ad-TSHR-, 4 Ad-GFP-immunized, and 7 native) mice were investigated. All native mice were negative for TSHR-binding inhibitory immunoglobulins (TBII) prior to immunization. Native and Ad-GFP mice were negative in weeks 17 and 27 for TBII and TBAb/TSAb. In native mice, the free thyroxine (fT4) levels (median [25th percentile; 75th percentile]) were in the upper normal range (1.2 ng/mL [1.1; 1.6]) prior to immunization, at weeks 17 (2.2 ng/mL [2.1; 2.4]) and 27 (1.4 ng/mL [1.1; 1.7]), respectively. In contrast, in Ad-TSHR-immunized mice, fT4 values were markedly increased at weeks 17 (4.4 ng/mL [3.9; 6]) and 27 (4.5 ng/mL [4.2; 6]) compared to those in Ad-GFP mice (2 ng/mL [1.8; 2.1] and 1.4 ng/mL [1.1; 1.6]), respectively (p = 0.0008, p = 0.001). In contrast, at week 17, in Ad-TSHR mice, the mean TBII, TBAb, and TSAb levels were 40 IU/L (40; 40); 62% inhibition (38; 69), and 116% SRR (97; 185), respectively; at week 27, they were 40 IU/L (39; 40); 65% inhibition (34; 80) and 95% SRR (63; 187), respectively. Three serum samples from Ad-TSHR mice (38%) demonstrated dual TBAb/TSAb positivity.TBAb/TSAb were highly prevalent in Ad-TSHR-immunized mice, thus confirming the successful establishment of a novel, long-term murine model for GD. All TBAb- and TSAb-positive Ad-TSHR-immunized mice were TBII-positive. Thus, the binding immunoassay did not differentiate between TSHR-Ab functionality." @default.
• W3044203957 created "2020-07-29" @default.
• W3044203957 creator A5001345102 @default.
• W3044203957 creator A5030690605 @default.
• W3044203957 creator A5048775489 @default.
• W3044203957 creator A5061859868 @default.
• W3044203957 creator A5063734732 @default.
• W3044203957 creator A5073320488 @default.
• W3044203957 creator A5087797414 @default.
• W3044203957 date "2020-01-01" @default.
• W3044203957 modified "2023-10-16" @default.
• W3044203957 title "A Novel Long-Term Graves’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies" @default.
• W3044203957 cites W1535627390 @default.
• W3044203957 cites W1571725622 @default.
• W3044203957 cites W1833485294 @default.
• W3044203957 cites W1833803062 @default.
• W3044203957 cites W1958761029 @default.
• W3044203957 cites W1991523626 @default.
• W3044203957 cites W2007471992 @default.
• W3044203957 cites W2030419597 @default.
• W3044203957 cites W2036018829 @default.
• W3044203957 cites W2043212719 @default.
• W3044203957 cites W2063476700 @default.
• W3044203957 cites W2068023129 @default.
• W3044203957 cites W2070992980 @default.
• W3044203957 cites W2075154147 @default.
• W3044203957 cites W2085640192 @default.
• W3044203957 cites W2095336326 @default.
• W3044203957 cites W2097050317 @default.
• W3044203957 cites W2109271955 @default.
• W3044203957 cites W2114679692 @default.
• W3044203957 cites W2144790804 @default.
• W3044203957 cites W2150675296 @default.
• W3044203957 cites W2155127310 @default.
• W3044203957 cites W2342019290 @default.
• W3044203957 cites W2407770516 @default.
• W3044203957 cites W2460731456 @default.
• W3044203957 cites W2547673960 @default.
• W3044203957 cites W2588222829 @default.
• W3044203957 cites W2609737451 @default.
• W3044203957 cites W2742639617 @default.
• W3044203957 cites W2805015628 @default.
• W3044203957 cites W2886132969 @default.
• W3044203957 cites W2894884627 @default.
• W3044203957 cites W2909266701 @default.
• W3044203957 cites W2912016695 @default.
• W3044203957 cites W2951839963 @default.
• W3044203957 cites W2996044668 @default.
• W3044203957 cites W3004796381 @default.
• W3044203957 cites W4248519364 @default.
• W3044203957 doi "https://doi.org/10.1159/000508790" @default.
• W3044203957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7802450" @default.
• W3044203957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33511085" @default.
• W3044203957 hasPublicationYear "2020" @default.
• W3044203957 type Work @default.
• W3044203957 sameAs 3044203957 @default.
• W3044203957 citedByCount "16" @default.
• W3044203957 countsByYear W30442039572020 @default.
• W3044203957 countsByYear W30442039572021 @default.
• W3044203957 countsByYear W30442039572022 @default.
• W3044203957 countsByYear W30442039572023 @default.
• W3044203957 crossrefType "journal-article" @default.
• W3044203957 hasAuthorship W3044203957A5001345102 @default.
• W3044203957 hasAuthorship W3044203957A5030690605 @default.
• W3044203957 hasAuthorship W3044203957A5048775489 @default.
• W3044203957 hasAuthorship W3044203957A5061859868 @default.
• W3044203957 hasAuthorship W3044203957A5063734732 @default.
• W3044203957 hasAuthorship W3044203957A5073320488 @default.
• W3044203957 hasAuthorship W3044203957A5087797414 @default.
• W3044203957 hasBestOaLocation W30442039571 @default.
• W3044203957 hasConcept C126322002 @default.
• W3044203957 hasConcept C134018914 @default.
• W3044203957 hasConcept C159654299 @default.
• W3044203957 hasConcept C163764329 @default.
• W3044203957 hasConcept C170493617 @default.
• W3044203957 hasConcept C203014093 @default.
• W3044203957 hasConcept C2776652619 @default.
• W3044203957 hasConcept C2777608072 @default.
• W3044203957 hasConcept C2779134260 @default.
• W3044203957 hasConcept C2780801004 @default.
• W3044203957 hasConcept C71924100 @default.
• W3044203957 hasConceptScore W3044203957C126322002 @default.
• W3044203957 hasConceptScore W3044203957C134018914 @default.
• W3044203957 hasConceptScore W3044203957C159654299 @default.
• W3044203957 hasConceptScore W3044203957C163764329 @default.
• W3044203957 hasConceptScore W3044203957C170493617 @default.
• W3044203957 hasConceptScore W3044203957C203014093 @default.
• W3044203957 hasConceptScore W3044203957C2776652619 @default.
• W3044203957 hasConceptScore W3044203957C2777608072 @default.
• W3044203957 hasConceptScore W3044203957C2779134260 @default.
• W3044203957 hasConceptScore W3044203957C2780801004 @default.
• W3044203957 hasConceptScore W3044203957C71924100 @default.
• W3044203957 hasIssue "Suppl. 1" @default.
• W3044203957 hasLocation W30442039571 @default.
• W3044203957 hasLocation W30442039572 @default.
• W3044203957 hasLocation W30442039573 @default.
• W3044203957 hasOpenAccess W3044203957 @default.
• W3044203957 hasPrimaryLocation W30442039571 @default.

• next