FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044206532> ?p ?o ?g. }

• W3044206532 endingPage "390" @default.
• W3044206532 startingPage "379" @default.
• W3044206532 abstract "Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets containing 60% kcal from fat (high-fat diet, HFD) or 10% kcal from fat (low-fat diet, LFD) and tested for metabolic (study 1) and behavioral (study 2) outcomes. In study 1, we measured glucose tolerance, fasting glucose and insulin, fat pad weights and despair-like behavior in the forced swim test (FST). In study 2, we assessed anxiety-like (elevated plus maze, EPM; open field test, OFT) and despair-like/coping (splash test, SpT; and FST) behaviors. Body weight and food intake were measured weekly in both studies. We found negative effects of HFD on metabolic outcomes, including increased body weight and fat pad weights, decreased glucose tolerance, and increased fasting insulin. We also found negative effects of HFD on despair-like/coping and anxiety-like behaviors. These include increased immobility in the FST, decreased open arm time in the EPM, and increased movement and rest episodes and decreased rearing in the OFT. The diet-induced changes in EPM and OFT were independent of overall locomotion. Additionally, diet-induced changes in OFT behaviors were independent of adiposity, while adiposity was a confounding factor for EPM and FST behavior. This work establishes the HS as a model to study gene by diet interactions affecting metabolic and behavioral health." @default.
• W3044206532 created "2020-07-29" @default.
• W3044206532 creator A5002154405 @default.
• W3044206532 creator A5002534463 @default.
• W3044206532 creator A5017480523 @default.
• W3044206532 creator A5033262024 @default.
• W3044206532 creator A5050979407 @default.
• W3044206532 creator A5058263538 @default.
• W3044206532 date "2020-09-01" @default.
• W3044206532 modified "2023-10-16" @default.
• W3044206532 title "High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats" @default.
• W3044206532 cites W1774706107 @default.
• W3044206532 cites W1822601256 @default.
• W3044206532 cites W1832133707 @default.
• W3044206532 cites W1854936925 @default.
• W3044206532 cites W1951724000 @default.
• W3044206532 cites W1970480986 @default.
• W3044206532 cites W1973316176 @default.
• W3044206532 cites W1974133478 @default.
• W3044206532 cites W1983691295 @default.
• W3044206532 cites W1986476152 @default.
• W3044206532 cites W1993606536 @default.
• W3044206532 cites W1994444281 @default.
• W3044206532 cites W1999807139 @default.
• W3044206532 cites W2004415631 @default.
• W3044206532 cites W2008697716 @default.
• W3044206532 cites W2013586266 @default.
• W3044206532 cites W2015751650 @default.
• W3044206532 cites W2017006044 @default.
• W3044206532 cites W2020184819 @default.
• W3044206532 cites W2022847943 @default.
• W3044206532 cites W2034355214 @default.
• W3044206532 cites W2039153962 @default.
• W3044206532 cites W2041561931 @default.
• W3044206532 cites W2064700156 @default.
• W3044206532 cites W2079369179 @default.
• W3044206532 cites W2088620464 @default.
• W3044206532 cites W2100226910 @default.
• W3044206532 cites W2100848362 @default.
• W3044206532 cites W2101762508 @default.
• W3044206532 cites W2112551996 @default.
• W3044206532 cites W2118165948 @default.
• W3044206532 cites W2132356956 @default.
• W3044206532 cites W2138330280 @default.
• W3044206532 cites W2140598936 @default.
• W3044206532 cites W2147953935 @default.
• W3044206532 cites W2156648025 @default.
• W3044206532 cites W2158218002 @default.
• W3044206532 cites W2171246514 @default.
• W3044206532 cites W2197078876 @default.
• W3044206532 cites W2216769371 @default.
• W3044206532 cites W2509772848 @default.
• W3044206532 cites W2588250592 @default.
• W3044206532 cites W2596798372 @default.
• W3044206532 cites W2606719128 @default.
• W3044206532 cites W2609163510 @default.
• W3044206532 cites W2611602179 @default.
• W3044206532 cites W2666620893 @default.
• W3044206532 cites W2735376054 @default.
• W3044206532 cites W2744159779 @default.
• W3044206532 cites W2746255098 @default.
• W3044206532 cites W2750397561 @default.
• W3044206532 cites W2754369369 @default.
• W3044206532 cites W2755118786 @default.
• W3044206532 cites W2765945674 @default.
• W3044206532 cites W2766503838 @default.
• W3044206532 cites W2771013630 @default.
• W3044206532 cites W2771639970 @default.
• W3044206532 cites W2779765029 @default.
• W3044206532 cites W2793219717 @default.
• W3044206532 cites W2898859410 @default.
• W3044206532 cites W2911657633 @default.
• W3044206532 cites W2915108784 @default.
• W3044206532 cites W2949375170 @default.
• W3044206532 cites W2951061344 @default.
• W3044206532 cites W2952883732 @default.
• W3044206532 doi "https://doi.org/10.1152/physiolgenomics.00018.2020" @default.
• W3044206532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7509248" @default.
• W3044206532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32687430" @default.
• W3044206532 hasPublicationYear "2020" @default.
• W3044206532 type Work @default.
• W3044206532 sameAs 3044206532 @default.
• W3044206532 citedByCount "9" @default.
• W3044206532 countsByYear W30442065322021 @default.
• W3044206532 countsByYear W30442065322022 @default.
• W3044206532 countsByYear W30442065322023 @default.
• W3044206532 crossrefType "journal-article" @default.
• W3044206532 hasAuthorship W3044206532A5002154405 @default.
• W3044206532 hasAuthorship W3044206532A5002534463 @default.
• W3044206532 hasAuthorship W3044206532A5017480523 @default.
• W3044206532 hasAuthorship W3044206532A5033262024 @default.
• W3044206532 hasAuthorship W3044206532A5050979407 @default.
• W3044206532 hasAuthorship W3044206532A5058263538 @default.
• W3044206532 hasBestOaLocation W30442065322 @default.
• W3044206532 hasConcept C118552586 @default.
• W3044206532 hasConcept C126322002 @default.
• W3044206532 hasConcept C134018914 @default.
• W3044206532 hasConcept C136569192 @default.

• next