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• W3044242495 startingPage "118129" @default.
• W3044242495 abstract "Ulcerative colitis (UC) is an inflammatory bowel disease with increasing incidence in the world, especially in developing countries. Although knowledge of its pathogenesis has progressed over the last years, some details require clarification. Studies have highlighted the role of microbial dysbiosis and immune dysfunction as essential factors that may initiate the typical high-grade inflammatory outcome. In order to better understand the immunopathophysiological aspects of UC, experimental murine models are valuable tools. Some of the most commonly used chemicals to induce colitis are trinitrobenzene sulfonic acid, oxazolone and dextran sodium sulfate. These may also be used to investigate new ways of preventing or treating UC and therefore improving targeting in human studies. The use of functional foods or bioactive compounds from plants may constitute an innovative direction towards the future of alternative medicine. Considering the above, this review focused on updated information regarding the 1. gut microbiota and immunopathogenesis of UC; 2. the most utilized animal models of the disease and their relevance; and 3. experimental application of natural products, not yet tested in clinical trials." @default.
• W3044242495 created "2020-07-29" @default.
• W3044242495 creator A5009286982 @default.
• W3044242495 creator A5022042674 @default.
• W3044242495 creator A5042101127 @default.
• W3044242495 creator A5054226083 @default.
• W3044242495 creator A5090170813 @default.
• W3044242495 date "2020-10-01" @default.
• W3044242495 modified "2023-10-17" @default.
• W3044242495 title "Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models" @default.
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