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• W3044244229 abstract "Patients with relapsed or refractory multiple myeloma (RRMM) represent an unmet clinical need. Belantamab mafodotin (belamaf; GSK2857916) is a first-in-class antibody-drug conjugate (ADC; or immunoconjugate) that delivers a cytotoxic payload, monomethyl auristatin F (MMAF), to myeloma cells. In the phase II DREAMM-2 study (NCT03525678), single-agent belamaf (2.5 mg/kg) demonstrated clinically meaningful anti-myeloma activity (overall response rate 32%) in patients with heavily pretreated disease. Microcyst-like epithelial changes (MECs) were common, consistent with reports from other MMAF-containing ADCs.Corneal examination findings from patients in DREAMM-2 were reviewed, and the clinical descriptions and accompanying images (slit lamp microscopy and in vivo confocal microscopy [IVCM]) of representative events were selected. A literature review on corneal events reported with other ADCs was performed.In most patients receiving single-agent belamaf (72%; 68/95), MECs were observed by slit lamp microscopy early in treatment (69% had their first event by dose 4). However, IVCM revealed hyperreflective material. Blurred vision (25%) and dry eye (15%) were commonly reported symptoms. Management of MECs included dose delays (47%)/reductions (25%), with few patients discontinuing due to MECs (1%). The first event resolved in most patients (grade ≥2 MECs and visual acuity [each 77%], blurred vision [67%], and dry eye [86%]), with no reports of permanent vision loss to date. A literature review confirmed that similar MECs were reported with other ADCs; however, event management strategies varied. The pathophysiology of MECs is unclear, though the ADC cytotoxic payload may contribute to on- or off-target effects on corneal epithelial cells.Single-agent belamaf represents a new treatment option for patients with RRMM. As with other ADCs, MECs were observed and additional research is warranted to determine their pathophysiology. A multidisciplinary approach, involving close collaboration between eye care professionals and hematologist/oncologists, is needed to determine appropriate diagnosis and management of these patients.ClinicalTrials.gov Identifier, NCT03525678." @default.
• W3044244229 created "2020-07-29" @default.
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• W3044244229 date "2020-07-25" @default.
• W3044244229 modified "2023-10-10" @default.
• W3044244229 title "Corneal Epithelial Findings in Patients with Multiple Myeloma Treated with Antibody–Drug Conjugate Belantamab Mafodotin in the Pivotal, Randomized, DREAMM-2 Study" @default.
• W3044244229 cites W1514713533 @default.
• W3044244229 cites W1968666284 @default.
• W3044244229 cites W1978406836 @default.
• W3044244229 cites W1982877913 @default.
• W3044244229 cites W2003092321 @default.
• W3044244229 cites W2034643565 @default.
• W3044244229 cites W2037607072 @default.
• W3044244229 cites W2042278402 @default.
• W3044244229 cites W2043958889 @default.
• W3044244229 cites W2056017799 @default.
• W3044244229 cites W2060012447 @default.
• W3044244229 cites W2061207508 @default.
• W3044244229 cites W2065528643 @default.
• W3044244229 cites W2076206706 @default.
• W3044244229 cites W2128192762 @default.
• W3044244229 cites W2153147430 @default.
• W3044244229 cites W2164337721 @default.
• W3044244229 cites W2184270030 @default.
• W3044244229 cites W2202939373 @default.
• W3044244229 cites W2262617296 @default.
• W3044244229 cites W2295236527 @default.
• W3044244229 cites W2315322079 @default.
• W3044244229 cites W2344489622 @default.
• W3044244229 cites W2377100349 @default.
• W3044244229 cites W2411430321 @default.
• W3044244229 cites W2486629951 @default.
• W3044244229 cites W2521731346 @default.
• W3044244229 cites W2561710991 @default.
• W3044244229 cites W2570141822 @default.
• W3044244229 cites W2581073208 @default.
• W3044244229 cites W2597800737 @default.
• W3044244229 cites W2625684162 @default.
• W3044244229 cites W2630481145 @default.
• W3044244229 cites W2726109867 @default.
• W3044244229 cites W2745539538 @default.
• W3044244229 cites W2765250662 @default.
• W3044244229 cites W2766906603 @default.
• W3044244229 cites W2791723605 @default.
• W3044244229 cites W2793831611 @default.
• W3044244229 cites W2798140657 @default.
• W3044244229 cites W2800949131 @default.
• W3044244229 cites W2804618127 @default.
• W3044244229 cites W2807016784 @default.
• W3044244229 cites W2809887713 @default.
• W3044244229 cites W2899388463 @default.
• W3044244229 cites W2900294328 @default.
• W3044244229 cites W2901760736 @default.
• W3044244229 cites W2903359836 @default.
• W3044244229 cites W2912396451 @default.
• W3044244229 cites W2914068327 @default.
• W3044244229 cites W2919531258 @default.
• W3044244229 cites W2921533600 @default.
• W3044244229 cites W2923666301 @default.
• W3044244229 cites W2940945106 @default.
• W3044244229 cites W2946687934 @default.
• W3044244229 cites W2952039293 @default.
• W3044244229 cites W2953684910 @default.
• W3044244229 cites W2972424269 @default.
• W3044244229 cites W2979807505 @default.
• W3044244229 cites W2995934717 @default.
• W3044244229 cites W3007877035 @default.
• W3044244229 cites W3008450454 @default.
• W3044244229 cites W3008716835 @default.
• W3044244229 cites W3016997058 @default.
• W3044244229 cites W3030811423 @default.
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• W3044244229 doi "https://doi.org/10.1007/s40123-020-00280-8" @default.
• W3044244229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7708586" @default.
• W3044244229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32920777" @default.
• W3044244229 hasPublicationYear "2020" @default.
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