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- W3044273225 endingPage "1081" @default.
- W3044273225 startingPage "1067" @default.
- W3044273225 abstract "Introduction Moxidectin is a milbemycin endectocide recently approved for the treatment of human onchocerciasis. Onchocerciasis, earmarked for elimination of transmission, is a filarial infection endemic in Africa, Yemen, and the Amazonian focus straddling Venezuela and Brazil. Concerns over whether the predominant treatment strategy (yearly mass drug administration (MDA) of ivermectin) is sufficient to achieve elimination in all endemic foci have refocussed attention upon alternative treatments. Moxidectin’s stronger and longer microfilarial suppression compared to ivermectin in both phase II and III clinical trials indicates its potential as a novel powerful drug for onchocerciasis elimination.Areas covered This work summarizes the chemistry and pharmacology of moxidectin, reviews the phase II and III clinical trials evidence on tolerability, safety, and efficacy of moxidectin versus ivermectin, and discusses the implications of moxidectin’s current regulatory status.Expert opinion Moxidectin’s superior clinical performance has the potential to substantially reduce times to elimination compared to ivermectin. If donated, moxidectin could mitigate the additional programmatic costs of biannual ivermectin distribution because, unlike other alternatives, it can use the existing community-directed treatment infrastructure. A pediatric indication (for children <12 years) and determination of its usefulness in onchocerciasis–loiasis co-endemic areas will greatly help fulfill the potential of moxidectin for the treatment and elimination of onchocerciasis." @default.
- W3044273225 created "2020-07-29" @default.
- W3044273225 creator A5031563853 @default.
- W3044273225 creator A5032519044 @default.
- W3044273225 creator A5040737387 @default.
- W3044273225 creator A5063396041 @default.
- W3044273225 date "2020-07-26" @default.
- W3044273225 modified "2023-10-17" @default.
- W3044273225 title "Moxidectin: an oral treatment for human onchocerciasis" @default.
- W3044273225 cites W1506862630 @default.
- W3044273225 cites W1549973279 @default.
- W3044273225 cites W1550107760 @default.
- W3044273225 cites W1585762477 @default.
- W3044273225 cites W1590485714 @default.
- W3044273225 cites W1891733169 @default.
- W3044273225 cites W1963864054 @default.
- W3044273225 cites W1967285730 @default.
- W3044273225 cites W1968208599 @default.
- W3044273225 cites W1972167875 @default.
- W3044273225 cites W1975239375 @default.
- W3044273225 cites W1980930218 @default.
- W3044273225 cites W1992109253 @default.
- W3044273225 cites W1993890387 @default.
- W3044273225 cites W1996800160 @default.
- W3044273225 cites W2000334503 @default.
- W3044273225 cites W2004422663 @default.
- W3044273225 cites W2006391573 @default.
- W3044273225 cites W2006626132 @default.
- W3044273225 cites W2007468463 @default.
- W3044273225 cites W2013305180 @default.
- W3044273225 cites W2013333615 @default.
- W3044273225 cites W2014582775 @default.
- W3044273225 cites W2015519080 @default.
- W3044273225 cites W2017192690 @default.
- W3044273225 cites W2017410078 @default.
- W3044273225 cites W2018664981 @default.
- W3044273225 cites W202012961 @default.
- W3044273225 cites W2039472587 @default.
- W3044273225 cites W2043074132 @default.
- W3044273225 cites W2047671536 @default.
- W3044273225 cites W2050587086 @default.
- W3044273225 cites W2056471774 @default.
- W3044273225 cites W2063851886 @default.
- W3044273225 cites W2064551035 @default.
- W3044273225 cites W2068127938 @default.
- W3044273225 cites W2071313132 @default.
- W3044273225 cites W2071685455 @default.
- W3044273225 cites W2084881364 @default.
- W3044273225 cites W2085069735 @default.
- W3044273225 cites W2087458512 @default.
- W3044273225 cites W2090402915 @default.
- W3044273225 cites W2092320439 @default.
- W3044273225 cites W2093119139 @default.
- W3044273225 cites W2097772387 @default.
- W3044273225 cites W2099542873 @default.
- W3044273225 cites W2101548438 @default.
- W3044273225 cites W2102990715 @default.
- W3044273225 cites W2104930292 @default.
- W3044273225 cites W2105272113 @default.
- W3044273225 cites W2114225347 @default.
- W3044273225 cites W2115463035 @default.
- W3044273225 cites W2117824521 @default.
- W3044273225 cites W2134666918 @default.
- W3044273225 cites W2136195730 @default.
- W3044273225 cites W2136581900 @default.
- W3044273225 cites W2138236452 @default.
- W3044273225 cites W2149843007 @default.
- W3044273225 cites W2150411620 @default.
- W3044273225 cites W2153086068 @default.
- W3044273225 cites W2159803598 @default.
- W3044273225 cites W2162650421 @default.
- W3044273225 cites W2167293860 @default.
- W3044273225 cites W2199621489 @default.
- W3044273225 cites W2290709861 @default.
- W3044273225 cites W2304118135 @default.
- W3044273225 cites W2320694512 @default.
- W3044273225 cites W2402708442 @default.
- W3044273225 cites W2417136506 @default.
- W3044273225 cites W2463359715 @default.
- W3044273225 cites W2487098937 @default.
- W3044273225 cites W2569382675 @default.
- W3044273225 cites W2591813347 @default.
- W3044273225 cites W2592238639 @default.
- W3044273225 cites W2599445270 @default.
- W3044273225 cites W2606036113 @default.
- W3044273225 cites W2737321623 @default.
- W3044273225 cites W2751792491 @default.
- W3044273225 cites W2765113454 @default.
- W3044273225 cites W2767594581 @default.
- W3044273225 cites W2770990838 @default.
- W3044273225 cites W2783063986 @default.
- W3044273225 cites W2792433576 @default.
- W3044273225 cites W2792721335 @default.
- W3044273225 cites W2792829840 @default.
- W3044273225 cites W2793917164 @default.
- W3044273225 cites W2794644679 @default.
- W3044273225 cites W2808864305 @default.
- W3044273225 cites W2809412284 @default.