FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044274263> ?p ?o ?g. }

• W3044274263 endingPage "1992" @default.
• W3044274263 startingPage "1983" @default.
• W3044274263 abstract "Lung cancer remains the leading cause of cancer death worldwide, with 15% to 20% occurring in never smokers. To assess genetic determinants for prognosis among never smokers, we conducted a genome-wide investigation in the International Lung Cancer Consortium (ILCCO).Genomic and clinical data from 1,569 never-smoking patients with lung cancer of European ancestry from 10 ILCCO studies were included. HRs and 95% confidence intervals of overall survival were estimated. We assessed whether the associations were mediated through mRNA expression-based 1,553 normal lung tissues from the lung expression quantitative trait loci (eQTL) dataset and Genotype-Tissue Expression (GTEx). For cross-ethnicity generalization, we assessed the associations in a Japanese study (N = 887).One locus at 13q22.2 was associated with lung adenocarcinoma survival at genome-wide level, with carriers of rs12875562-T allele exhibiting poor prognosis [HR = 1.71 (1.41-2.07), P = 3.60 × 10-8], and altered mRNA expression of LMO7DN in lung tissue (GTEx, P = 9.40 × 10-7; Lung eQTL dataset, P = 0.003). Furthermore, 2 of 11 independent loci that reached the suggestive significance level (P < 10-6) were significant eQTL affecting mRNA expression of nearby genes in lung tissues, including CAPZB at 1p36.13 and UBAC1 at 9q34.3. One locus encoding NWD2/KIAA1239 at 4p14 showed associations in both European [HR = 0.50 (0.38-0.66), P = 6.92 × 10-7] and Japanese populations [HR = 0.79 (0.67-0.94), P = 0.007].Based on the largest genomic investigation on the lung cancer prognosis of never smokers to date, we observed that lung cancer prognosis is affected by inherited genetic variants.We identified one locus near LMO7DN at genome-wide level and several potential prognostic genes with cis-effect on mRNA expression. Further functional genomics work is required to understand their role in tumor progression." @default.
• W3044274263 created "2020-07-29" @default.
• W3044274263 creator A5002857362 @default.
• W3044274263 creator A5004491112 @default.
• W3044274263 creator A5014404772 @default.
• W3044274263 creator A5022511267 @default.
• W3044274263 creator A5023176957 @default.
• W3044274263 creator A5023531951 @default.
• W3044274263 creator A5025520229 @default.
• W3044274263 creator A5028989565 @default.
• W3044274263 creator A5034359692 @default.
• W3044274263 creator A5051132319 @default.
• W3044274263 creator A5053712654 @default.
• W3044274263 creator A5066879936 @default.
• W3044274263 creator A5077109568 @default.
• W3044274263 creator A5086376470 @default.
• W3044274263 creator A5091331939 @default.
• W3044274263 date "2020-10-01" @default.
• W3044274263 modified "2023-10-17" @default.
• W3044274263 title "Genetic Determinants of Lung Cancer Prognosis in Never Smokers: A Pooled Analysis in the International Lung Cancer Consortium" @default.
• W3044274263 cites W1533942137 @default.
• W3044274263 cites W1574189324 @default.
• W3044274263 cites W1804932677 @default.
• W3044274263 cites W1965768540 @default.
• W3044274263 cites W1972020976 @default.
• W3044274263 cites W1977796312 @default.
• W3044274263 cites W1991253843 @default.
• W3044274263 cites W1993430248 @default.
• W3044274263 cites W2007846880 @default.
• W3044274263 cites W2023026302 @default.
• W3044274263 cites W2026884584 @default.
• W3044274263 cites W2035070850 @default.
• W3044274263 cites W2041992600 @default.
• W3044274263 cites W2067153802 @default.
• W3044274263 cites W2072733812 @default.
• W3044274263 cites W2087036932 @default.
• W3044274263 cites W2092974902 @default.
• W3044274263 cites W2097805950 @default.
• W3044274263 cites W2098209113 @default.
• W3044274263 cites W2099462145 @default.
• W3044274263 cites W2111307685 @default.
• W3044274263 cites W2118082971 @default.
• W3044274263 cites W2120240963 @default.
• W3044274263 cites W2125435699 @default.
• W3044274263 cites W2129774558 @default.
• W3044274263 cites W2131876608 @default.
• W3044274263 cites W2133520037 @default.
• W3044274263 cites W2137497598 @default.
• W3044274263 cites W2138145250 @default.
• W3044274263 cites W2148351250 @default.
• W3044274263 cites W2157752701 @default.
• W3044274263 cites W2166501262 @default.
• W3044274263 cites W2168254126 @default.
• W3044274263 cites W2294326811 @default.
• W3044274263 cites W2528850048 @default.
• W3044274263 cites W2566908060 @default.
• W3044274263 cites W2573109541 @default.
• W3044274263 cites W2612427157 @default.
• W3044274263 cites W2620270887 @default.
• W3044274263 cites W2620431387 @default.
• W3044274263 cites W2724116530 @default.
• W3044274263 cites W2777667999 @default.
• W3044274263 cites W2809588124 @default.
• W3044274263 cites W2889646458 @default.
• W3044274263 cites W2894150395 @default.
• W3044274263 cites W2947236019 @default.
• W3044274263 cites W2982722051 @default.
• W3044274263 cites W2984981484 @default.
• W3044274263 cites W4297900711 @default.
• W3044274263 doi "https://doi.org/10.1158/1055-9965.epi-20-0248" @default.
• W3044274263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7541720" @default.
• W3044274263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32699080" @default.
• W3044274263 hasPublicationYear "2020" @default.
• W3044274263 type Work @default.
• W3044274263 sameAs 3044274263 @default.
• W3044274263 citedByCount "8" @default.
• W3044274263 countsByYear W30442742632020 @default.
• W3044274263 countsByYear W30442742632021 @default.
• W3044274263 countsByYear W30442742632023 @default.
• W3044274263 crossrefType "journal-article" @default.
• W3044274263 hasAuthorship W3044274263A5002857362 @default.
• W3044274263 hasAuthorship W3044274263A5004491112 @default.
• W3044274263 hasAuthorship W3044274263A5014404772 @default.
• W3044274263 hasAuthorship W3044274263A5022511267 @default.
• W3044274263 hasAuthorship W3044274263A5023176957 @default.
• W3044274263 hasAuthorship W3044274263A5023531951 @default.
• W3044274263 hasAuthorship W3044274263A5025520229 @default.
• W3044274263 hasAuthorship W3044274263A5028989565 @default.
• W3044274263 hasAuthorship W3044274263A5034359692 @default.
• W3044274263 hasAuthorship W3044274263A5051132319 @default.
• W3044274263 hasAuthorship W3044274263A5053712654 @default.
• W3044274263 hasAuthorship W3044274263A5066879936 @default.
• W3044274263 hasAuthorship W3044274263A5077109568 @default.
• W3044274263 hasAuthorship W3044274263A5086376470 @default.
• W3044274263 hasAuthorship W3044274263A5091331939 @default.
• W3044274263 hasBestOaLocation W30442742631 @default.
• W3044274263 hasConcept C104317684 @default.
• W3044274263 hasConcept C106208931 @default.

• next