FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044286795> ?p ?o ?g. }

• W3044286795 abstract "Abstract Alzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disorder and one of the leading causes of death in the United States. Although amyloid plaques and fibrillary tangles are hallmarks of AD, research suggests that pathology associated with AD often begins 20 or more years before symptoms appear. Therefore, it is essential to identify early-stage biomarkers in those at risk for AD and age-related cognitive decline (ARCD) in order to develop preventative treatments. Here, we used an untargeted metabolomics analysis to define system-level alterations following cognitive decline in aged and APP/PS1 (AD) mice. At 6, 12, and 24 months of age, both control (Ctrl) and AD mice were tested in a 3-shock contextual fear conditioning (CFC) paradigm to assess memory decline. AD mice exhibited memory deficits across age and these memory deficits were also seen in naturally aged mice. Prefrontal cortex (PFC), hippocampus (HPC), and spleen were then collected and analyzed for metabolomic alterations. A number of significant pathways were altered between Ctrl and AD mice and naturally aged mice. By identifying systems-level alterations following ARCD and AD, these data could provide insights into disease mechanisms and advance the development of biomarker panels." @default.
• W3044286795 created "2020-07-29" @default.
• W3044286795 creator A5008685777 @default.
• W3044286795 creator A5016790931 @default.
• W3044286795 creator A5027515817 @default.
• W3044286795 creator A5058081424 @default.
• W3044286795 creator A5079252699 @default.
• W3044286795 creator A5082607061 @default.
• W3044286795 date "2020-07-22" @default.
• W3044286795 modified "2023-10-05" @default.
• W3044286795 title "Divergence in the metabolome between natural aging and Alzheimer’s disease" @default.
• W3044286795 cites W1573348274 @default.
• W3044286795 cites W1604272660 @default.
• W3044286795 cites W1660684267 @default.
• W3044286795 cites W1690235847 @default.
• W3044286795 cites W1835461481 @default.
• W3044286795 cites W1858579514 @default.
• W3044286795 cites W1959882307 @default.
• W3044286795 cites W1965237996 @default.
• W3044286795 cites W1968592020 @default.
• W3044286795 cites W1980925491 @default.
• W3044286795 cites W1984390450 @default.
• W3044286795 cites W1986847304 @default.
• W3044286795 cites W1989669360 @default.
• W3044286795 cites W1998299486 @default.
• W3044286795 cites W2001171907 @default.
• W3044286795 cites W2005727835 @default.
• W3044286795 cites W2006565594 @default.
• W3044286795 cites W2014965759 @default.
• W3044286795 cites W2015429211 @default.
• W3044286795 cites W2036362108 @default.
• W3044286795 cites W2040426212 @default.
• W3044286795 cites W2041255286 @default.
• W3044286795 cites W2041361760 @default.
• W3044286795 cites W2043929417 @default.
• W3044286795 cites W2045641489 @default.
• W3044286795 cites W2046775696 @default.
• W3044286795 cites W2049733019 @default.
• W3044286795 cites W2060011496 @default.
• W3044286795 cites W2065750082 @default.
• W3044286795 cites W2067975928 @default.
• W3044286795 cites W2069368135 @default.
• W3044286795 cites W2071068165 @default.
• W3044286795 cites W2073778714 @default.
• W3044286795 cites W2078380411 @default.
• W3044286795 cites W2080705044 @default.
• W3044286795 cites W2082005347 @default.
• W3044286795 cites W2085974955 @default.
• W3044286795 cites W2086692662 @default.
• W3044286795 cites W2088459134 @default.
• W3044286795 cites W2092512185 @default.
• W3044286795 cites W2096337635 @default.
• W3044286795 cites W2101077392 @default.
• W3044286795 cites W2106658334 @default.
• W3044286795 cites W2108493635 @default.
• W3044286795 cites W2124121471 @default.
• W3044286795 cites W2135624089 @default.
• W3044286795 cites W2138793403 @default.
• W3044286795 cites W2145265944 @default.
• W3044286795 cites W2150509537 @default.
• W3044286795 cites W2159671087 @default.
• W3044286795 cites W2163875615 @default.
• W3044286795 cites W2172196972 @default.
• W3044286795 cites W2215675716 @default.
• W3044286795 cites W2277679914 @default.
• W3044286795 cites W2295054364 @default.
• W3044286795 cites W2300480290 @default.
• W3044286795 cites W2327790265 @default.
• W3044286795 cites W2336066647 @default.
• W3044286795 cites W2339053999 @default.
• W3044286795 cites W2402030719 @default.
• W3044286795 cites W2419604885 @default.
• W3044286795 cites W2521929254 @default.
• W3044286795 cites W2525313139 @default.
• W3044286795 cites W2587271565 @default.
• W3044286795 cites W2604754546 @default.
• W3044286795 cites W2614739342 @default.
• W3044286795 cites W2733001097 @default.
• W3044286795 cites W2734619548 @default.
• W3044286795 cites W2739646638 @default.
• W3044286795 cites W2783358291 @default.
• W3044286795 cites W2789441331 @default.
• W3044286795 cites W2791633767 @default.
• W3044286795 cites W2793911225 @default.
• W3044286795 cites W2795195933 @default.
• W3044286795 cites W2803784647 @default.
• W3044286795 cites W2904361233 @default.
• W3044286795 cites W2904703254 @default.
• W3044286795 cites W2974361058 @default.
• W3044286795 cites W2989855650 @default.
• W3044286795 cites W2998707549 @default.
• W3044286795 cites W4211050998 @default.
• W3044286795 doi "https://doi.org/10.1038/s41598-020-68739-z" @default.
• W3044286795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7376199" @default.
• W3044286795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32699218" @default.
• W3044286795 hasPublicationYear "2020" @default.
• W3044286795 type Work @default.
• W3044286795 sameAs 3044286795 @default.
• W3044286795 citedByCount "17" @default.
• W3044286795 countsByYear W30442867952021 @default.

• next