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• W3044291659 endingPage "838" @default.
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• W3044291659 abstract "Abstract Background Stressful life events (SLEs) are associated with hyper(re-)activity of the HPA-axis. HPA-axis hyper(re-)activity is thought to be a major risk factor for depression development. SLEs may induce changes in an organism's stress system via epigenetic mechanisms. The neuropeptide oxytocin (OT) is able to attenuate the stress response, and OT pathways are dysregulated in individuals suffering from Major Depressive Disorder (MDD). Therefore, the gene coding for oxytocin (OXT) is a possible target for the investigation of depression development. Methods We collected data on SLEs, OXT promoter methylation (Sequenom Epityper MassArray) and depression severity from 90 MDD inpatients and 90 matched healthy controls. Results We found MDD inpatients to have a significantly lower OXT methylation than healthy controls. Methylation status was significantly negatively associated with SLEs but only in the group of MDD inpatients. There were no associations between methylation status and depression severity. Limitations Methylation in blood samples is only a proxy for epigenetic profiles in brain tissue. We did not assess mRNA or protein levels and cannot draw conclusions regarding the functionality or specificity of differences in OXT methylation between groups. Conclusion SLEs leave their traces in the epigenetic profiles of the OT system of MDD inpatients. Alterations in epigenetic profiles of the OXT system could constitute a vulnerability factor predisposing individuals for depression development. Better understanding of DNA methylation profiles of depression-associated genes could serve as basis for a personalized medicine, in which pharmacological or psychotherapeutic treatment of depression is tailored to the patient's individual characteristics." @default.
• W3044291659 created "2020-07-29" @default.
• W3044291659 creator A5020742914 @default.
• W3044291659 creator A5022713595 @default.
• W3044291659 creator A5053174321 @default.
• W3044291659 creator A5081287530 @default.
• W3044291659 date "2020-11-01" @default.
• W3044291659 modified "2023-09-24" @default.
• W3044291659 title "Relation of promoter methylation of the structural oxytocin gene to critical life events in major depression: A case control study" @default.
• W3044291659 cites W1555378511 @default.
• W3044291659 cites W1876466633 @default.
• W3044291659 cites W1939174019 @default.
• W3044291659 cites W1942677302 @default.
• W3044291659 cites W1951724000 @default.
• W3044291659 cites W1969736791 @default.
• W3044291659 cites W1970297103 @default.
• W3044291659 cites W1971328065 @default.
• W3044291659 cites W1972200797 @default.
• W3044291659 cites W1975265345 @default.
• W3044291659 cites W1978020297 @default.
• W3044291659 cites W1992351596 @default.
• W3044291659 cites W1992393512 @default.
• W3044291659 cites W1996368170 @default.
• W3044291659 cites W1999272870 @default.
• W3044291659 cites W1999478182 @default.
• W3044291659 cites W2001142434 @default.
• W3044291659 cites W2004251120 @default.
• W3044291659 cites W2016017492 @default.
• W3044291659 cites W2018630482 @default.
• W3044291659 cites W2022226725 @default.
• W3044291659 cites W2022320465 @default.
• W3044291659 cites W2024994042 @default.
• W3044291659 cites W2040402447 @default.
• W3044291659 cites W2043583999 @default.
• W3044291659 cites W2069300470 @default.
• W3044291659 cites W2070460280 @default.
• W3044291659 cites W2078028724 @default.
• W3044291659 cites W2081762124 @default.
• W3044291659 cites W2082066835 @default.
• W3044291659 cites W2084118479 @default.
• W3044291659 cites W2085062396 @default.
• W3044291659 cites W2106894252 @default.
• W3044291659 cites W2120013686 @default.
• W3044291659 cites W2130907138 @default.
• W3044291659 cites W2131823335 @default.
• W3044291659 cites W2132152083 @default.
• W3044291659 cites W2133797372 @default.
• W3044291659 cites W2140660757 @default.
• W3044291659 cites W2143079975 @default.
• W3044291659 cites W2146551770 @default.
• W3044291659 cites W2149050611 @default.
• W3044291659 cites W2151541902 @default.
• W3044291659 cites W2152849583 @default.
• W3044291659 cites W2155351060 @default.
• W3044291659 cites W2166080612 @default.
• W3044291659 cites W2167532031 @default.
• W3044291659 cites W2170760271 @default.
• W3044291659 cites W2171340584 @default.
• W3044291659 cites W2253842536 @default.
• W3044291659 cites W2338600154 @default.
• W3044291659 cites W2441453408 @default.
• W3044291659 cites W2465150027 @default.
• W3044291659 cites W2468712760 @default.
• W3044291659 cites W2468956824 @default.
• W3044291659 cites W2489540655 @default.
• W3044291659 cites W2518848630 @default.
• W3044291659 cites W2550344514 @default.
• W3044291659 cites W2554464434 @default.
• W3044291659 cites W2556416735 @default.
• W3044291659 cites W2625101985 @default.
• W3044291659 cites W2631752818 @default.
• W3044291659 cites W2735059498 @default.
• W3044291659 cites W2739650445 @default.
• W3044291659 cites W2765504358 @default.
• W3044291659 cites W2791519824 @default.
• W3044291659 cites W2802228122 @default.
• W3044291659 cites W2899583475 @default.
• W3044291659 cites W2901686750 @default.
• W3044291659 cites W2902100905 @default.
• W3044291659 cites W2909075979 @default.
• W3044291659 cites W2909598371 @default.
• W3044291659 cites W2914239254 @default.
• W3044291659 cites W2918191910 @default.
• W3044291659 cites W2937282400 @default.
• W3044291659 cites W2952786557 @default.
• W3044291659 cites W2971873523 @default.
• W3044291659 cites W2973866779 @default.
• W3044291659 cites W2981171417 @default.
• W3044291659 cites W3001888994 @default.
• W3044291659 cites W3008523340 @default.
• W3044291659 cites W4250664039 @default.
• W3044291659 cites W611051872 @default.
• W3044291659 doi "https://doi.org/10.1016/j.jad.2020.07.068" @default.
• W3044291659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32738668" @default.
• W3044291659 hasPublicationYear "2020" @default.
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