FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044292204> ?p ?o ?g. }

• W3044292204 endingPage "15" @default.
• W3044292204 startingPage "1" @default.
• W3044292204 abstract "To evaluate the diagnostic potential of [-2] proPSA (p2PSA), %p2PSA, Prostate Health Index (phi), and phi density (PHID) as independent biomarkers and in composition of multivariable models in predicting high-grade prostatic intraepithelial neoplasia (HGPIN) and overall and clinically significant prostate cancer (PCa).210 males scheduled for prostate biopsy with total PSA (tPSA) range 2-10 ng/mL and normal digital rectal examination were enrolled in the prospective study. Blood samples to measure tPSA, free PSA (fPSA), and p2PSA were collected immediately before 12-core prostate biopsy. Clinically significant PCa definition was based on Epstein's criteria or ISUP grade ≥ 2 at biopsy.PCa has been diagnosed in 112 (53.3%) patients. Epstein significant and ISUP grade ≥ 2 PCa have been identified in 81 (72.3%) and 40 (35.7%) patients, respectively. Isolated HGPIN at biopsy have been identified in 24 (11.4%) patients. Higher p2PSA and its derivative mean values were associated with PCa. At 90% sensitivity, PHID with cut-off value of 0.54 have demonstrated the highest sensitivity of 35.7% for overall PCa detection, so PHID and phi with cut-off values of 33.2 and 0.63 have demonstrated the specificity of 34.7% and 34.1% for ISUP grade ≥ 2 PCa detection at biopsy, respectively. In univariate ROC analysis, PHID with AUC of 0.77 and 0.80 was the most accurate predictor of overall and Epstein significant PCa, respectively, so phi with AUC of 0.77 was the most accurate predictor of ISUP grade ≥ 2 PCa at biopsy. In multivariate logistic regression analysis, phi improved diagnostic accuracy of multivariable models by 5% in predicting ISUP grade ≥ 2 PCa.PHID and phi have shown the greatest specificity at 90% sensitivity in predicting overall and clinically significant PCa and would lead to significantly avoid unnecessary biopsies. PHID is the most accurate predictor of overall and Epstein significant PCa, so phi is the most accurate predictor of ISUP grade ≥ 2 PCa. phi significantly improves the diagnostic accuracy of multivariable models in predicting ISUP grade ≥ 2 PCa." @default.
• W3044292204 created "2020-07-29" @default.
• W3044292204 creator A5011621315 @default.
• W3044292204 creator A5015438825 @default.
• W3044292204 creator A5031706594 @default.
• W3044292204 creator A5033458208 @default.
• W3044292204 creator A5040096374 @default.
• W3044292204 creator A5055245886 @default.
• W3044292204 creator A5060132464 @default.
• W3044292204 creator A5062211039 @default.
• W3044292204 date "2020-07-22" @default.
• W3044292204 modified "2023-10-15" @default.
• W3044292204 title "Prostate Health Index and Prostate Health Index Density as Diagnostic Tools for Improved Prostate Cancer Detection" @default.
• W3044292204 cites W1492152799 @default.
• W3044292204 cites W1757407923 @default.
• W3044292204 cites W1925864021 @default.
• W3044292204 cites W1966857251 @default.
• W3044292204 cites W1969825763 @default.
• W3044292204 cites W1970876554 @default.
• W3044292204 cites W1976141589 @default.
• W3044292204 cites W1985784441 @default.
• W3044292204 cites W1992578553 @default.
• W3044292204 cites W2016016515 @default.
• W3044292204 cites W2020293070 @default.
• W3044292204 cites W2035809577 @default.
• W3044292204 cites W2045030989 @default.
• W3044292204 cites W2072315075 @default.
• W3044292204 cites W2098546186 @default.
• W3044292204 cites W2103764347 @default.
• W3044292204 cites W2111089373 @default.
• W3044292204 cites W2117169320 @default.
• W3044292204 cites W2128536507 @default.
• W3044292204 cites W2140687262 @default.
• W3044292204 cites W2144762283 @default.
• W3044292204 cites W2148934838 @default.
• W3044292204 cites W2151523929 @default.
• W3044292204 cites W2328176404 @default.
• W3044292204 cites W2340422569 @default.
• W3044292204 cites W2531555178 @default.
• W3044292204 cites W2569460303 @default.
• W3044292204 cites W2789262688 @default.
• W3044292204 cites W2803748465 @default.
• W3044292204 cites W2889646458 @default.
• W3044292204 cites W3006593269 @default.
• W3044292204 cites W4242570784 @default.
• W3044292204 doi "https://doi.org/10.1155/2020/9872146" @default.
• W3044292204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7396080" @default.
• W3044292204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32775459" @default.
• W3044292204 hasPublicationYear "2020" @default.
• W3044292204 type Work @default.
• W3044292204 sameAs 3044292204 @default.
• W3044292204 citedByCount "16" @default.
• W3044292204 countsByYear W30442922042021 @default.
• W3044292204 countsByYear W30442922042022 @default.
• W3044292204 countsByYear W30442922042023 @default.
• W3044292204 crossrefType "journal-article" @default.
• W3044292204 hasAuthorship W3044292204A5011621315 @default.
• W3044292204 hasAuthorship W3044292204A5015438825 @default.
• W3044292204 hasAuthorship W3044292204A5031706594 @default.
• W3044292204 hasAuthorship W3044292204A5033458208 @default.
• W3044292204 hasAuthorship W3044292204A5040096374 @default.
• W3044292204 hasAuthorship W3044292204A5055245886 @default.
• W3044292204 hasAuthorship W3044292204A5060132464 @default.
• W3044292204 hasAuthorship W3044292204A5062211039 @default.
• W3044292204 hasBestOaLocation W30442922041 @default.
• W3044292204 hasConcept C121608353 @default.
• W3044292204 hasConcept C126322002 @default.
• W3044292204 hasConcept C126894567 @default.
• W3044292204 hasConcept C144301174 @default.
• W3044292204 hasConcept C2775934546 @default.
• W3044292204 hasConcept C2776235491 @default.
• W3044292204 hasConcept C2779534503 @default.
• W3044292204 hasConcept C2780101318 @default.
• W3044292204 hasConcept C2780192828 @default.
• W3044292204 hasConcept C2781217009 @default.
• W3044292204 hasConcept C38180746 @default.
• W3044292204 hasConcept C71924100 @default.
• W3044292204 hasConceptScore W3044292204C121608353 @default.
• W3044292204 hasConceptScore W3044292204C126322002 @default.
• W3044292204 hasConceptScore W3044292204C126894567 @default.
• W3044292204 hasConceptScore W3044292204C144301174 @default.
• W3044292204 hasConceptScore W3044292204C2775934546 @default.
• W3044292204 hasConceptScore W3044292204C2776235491 @default.
• W3044292204 hasConceptScore W3044292204C2779534503 @default.
• W3044292204 hasConceptScore W3044292204C2780101318 @default.
• W3044292204 hasConceptScore W3044292204C2780192828 @default.
• W3044292204 hasConceptScore W3044292204C2781217009 @default.
• W3044292204 hasConceptScore W3044292204C38180746 @default.
• W3044292204 hasConceptScore W3044292204C71924100 @default.
• W3044292204 hasLocation W30442922041 @default.
• W3044292204 hasLocation W30442922042 @default.
• W3044292204 hasLocation W30442922043 @default.
• W3044292204 hasOpenAccess W3044292204 @default.
• W3044292204 hasPrimaryLocation W30442922041 @default.
• W3044292204 hasRelatedWork W1570285055 @default.
• W3044292204 hasRelatedWork W1979374145 @default.
• W3044292204 hasRelatedWork W2099948048 @default.
• W3044292204 hasRelatedWork W2102167265 @default.

• next