Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044297966> ?p ?o ?g. }
- W3044297966 abstract "Motivated by experimental observations in 3D/organoid cultures derived from glioblastoma, we develop a mathematical model where tumour aggregate formation is obtained as the result of nutrient-limited cell proliferation coupled with chemotaxis-based cell movement. The introduction of a chemotherapeutic treatment induces mechanical changes at the cell level, with cells undergoing a transition from rigid bodies to semi-elastic entities. We analyse the influence of these individual mechanical changes on the properties of the aggregates obtained at the population level by introducing a nonlinear volume-filling chemotactic system of partial differential equations. The elastic properties of the cells are taken into account through the so-called squeezing probability, which allows us to change the packing capacity of the aggregates, depending on the concentration of the treatment in the extracellular microenvironment. We explore two scenarios for the effect of the treatment: firstly, the treatment acts only on the mechanical properties of the cells and, secondly, we assume it also prevents cell proliferation. A linear stability analysis enables us to study the ability of the system to create patterns. We provide numerical simulations in 1D and 2D that illustrate the shrinking of the aggregates due to the presence of the treatment." @default.
- W3044297966 created "2020-07-29" @default.
- W3044297966 creator A5011370355 @default.
- W3044297966 creator A5018282856 @default.
- W3044297966 creator A5027603422 @default.
- W3044297966 creator A5028466138 @default.
- W3044297966 creator A5058373489 @default.
- W3044297966 creator A5079602974 @default.
- W3044297966 date "2020-07-24" @default.
- W3044297966 modified "2023-10-02" @default.
- W3044297966 title "Treatment-induced shrinking of tumour aggregates: A nonlinear volume-filling chemotactic approach" @default.
- W3044297966 cites W1217515891 @default.
- W3044297966 cites W1534983138 @default.
- W3044297966 cites W1677602772 @default.
- W3044297966 cites W1856717255 @default.
- W3044297966 cites W1970613379 @default.
- W3044297966 cites W1981659355 @default.
- W3044297966 cites W1987347396 @default.
- W3044297966 cites W1999147594 @default.
- W3044297966 cites W1999476677 @default.
- W3044297966 cites W2001752971 @default.
- W3044297966 cites W2014527760 @default.
- W3044297966 cites W2018404967 @default.
- W3044297966 cites W2021117151 @default.
- W3044297966 cites W2027061665 @default.
- W3044297966 cites W2033835339 @default.
- W3044297966 cites W2046495918 @default.
- W3044297966 cites W2047506587 @default.
- W3044297966 cites W2061108300 @default.
- W3044297966 cites W2065877884 @default.
- W3044297966 cites W2071867803 @default.
- W3044297966 cites W2074203477 @default.
- W3044297966 cites W2075718843 @default.
- W3044297966 cites W2085924650 @default.
- W3044297966 cites W2089482729 @default.
- W3044297966 cites W2096287682 @default.
- W3044297966 cites W2102356696 @default.
- W3044297966 cites W2117692326 @default.
- W3044297966 cites W2118687720 @default.
- W3044297966 cites W2129160559 @default.
- W3044297966 cites W2133662989 @default.
- W3044297966 cites W2146103275 @default.
- W3044297966 cites W2146354638 @default.
- W3044297966 cites W2158681922 @default.
- W3044297966 cites W2160509269 @default.
- W3044297966 cites W2164282019 @default.
- W3044297966 cites W2165485564 @default.
- W3044297966 cites W2169659086 @default.
- W3044297966 cites W2169917705 @default.
- W3044297966 cites W2324363591 @default.
- W3044297966 cites W2366536035 @default.
- W3044297966 cites W2392045628 @default.
- W3044297966 cites W2460465955 @default.
- W3044297966 cites W2551309609 @default.
- W3044297966 cites W2605795763 @default.
- W3044297966 cites W2738029723 @default.
- W3044297966 cites W2767326874 @default.
- W3044297966 cites W2789065958 @default.
- W3044297966 cites W2794730880 @default.
- W3044297966 cites W2802896169 @default.
- W3044297966 cites W2803141230 @default.
- W3044297966 cites W2896032894 @default.
- W3044297966 cites W2945894447 @default.
- W3044297966 cites W2987126840 @default.
- W3044297966 cites W3006006934 @default.
- W3044297966 cites W3025246673 @default.
- W3044297966 cites W3033325097 @default.
- W3044297966 cites W3042469697 @default.
- W3044297966 cites W3048251357 @default.
- W3044297966 hasPublicationYear "2020" @default.
- W3044297966 type Work @default.
- W3044297966 sameAs 3044297966 @default.
- W3044297966 citedByCount "0" @default.
- W3044297966 crossrefType "posted-content" @default.
- W3044297966 hasAuthorship W3044297966A5011370355 @default.
- W3044297966 hasAuthorship W3044297966A5018282856 @default.
- W3044297966 hasAuthorship W3044297966A5027603422 @default.
- W3044297966 hasAuthorship W3044297966A5028466138 @default.
- W3044297966 hasAuthorship W3044297966A5058373489 @default.
- W3044297966 hasAuthorship W3044297966A5079602974 @default.
- W3044297966 hasConcept C112972136 @default.
- W3044297966 hasConcept C119857082 @default.
- W3044297966 hasConcept C121332964 @default.
- W3044297966 hasConcept C12554922 @default.
- W3044297966 hasConcept C134306372 @default.
- W3044297966 hasConcept C144024400 @default.
- W3044297966 hasConcept C1491633281 @default.
- W3044297966 hasConcept C149923435 @default.
- W3044297966 hasConcept C158622935 @default.
- W3044297966 hasConcept C170493617 @default.
- W3044297966 hasConcept C171250308 @default.
- W3044297966 hasConcept C185592680 @default.
- W3044297966 hasConcept C192562407 @default.
- W3044297966 hasConcept C2908647359 @default.
- W3044297966 hasConcept C3017564526 @default.
- W3044297966 hasConcept C31695470 @default.
- W3044297966 hasConcept C33923547 @default.
- W3044297966 hasConcept C41008148 @default.
- W3044297966 hasConcept C4679612 @default.
- W3044297966 hasConcept C54166955 @default.