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- W3044303452 abstract "Dictyostelium discoideum, the model organism for the evolutionary supergroup of Amoebozoa, is a social amoeba that, upon starvation, undergoes transition from a unicellular to a multicellular organism. In its genome, we identified two genes encoding for tRNA nucleotidyltransferases. Such pairs of tRNA nucleotidyltransferases usually represent collaborating partial activities catalyzing CC- and A-addition to the tRNA 3′-end, respectively. In D. discoideum, however, both enzymes exhibit identical activities, representing bona-fide CCA-adding enzymes. Detailed characterization of the corresponding activities revealed that both enzymes seem to be essential and are regulated inversely during different developmental stages of D. discoideum. Intriguingly, this is the first description of two functionally equivalent CCA-adding enzymes using the same set of tRNAs and showing a similar distribution within the cell. This situation seems to be a common feature in Dictyostelia, as other members of this phylum carry similar pairs of tRNA nucleotidyltransferase genes in their genome." @default.
- W3044303452 created "2020-07-29" @default.
- W3044303452 creator A5014629170 @default.
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- W3044303452 creator A5089296618 @default.
- W3044303452 date "2020-07-23" @default.
- W3044303452 modified "2023-10-03" @default.
- W3044303452 title "Unusual Occurrence of Two Bona-Fide CCA-Adding Enzymes in Dictyostelium discoideum" @default.
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