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- W3044303841 endingPage "1774" @default.
- W3044303841 startingPage "1774" @default.
- W3044303841 abstract "Decades of active research have shown that mitochondrial dysfunction, the associated oxidative stress, impaired anti-stress defense mechanisms, and the activation of the proapoptotic signaling pathways underlie pathological changes in organs and tissues. Pathologies caused by alcohol primarily affect the liver. Alcohol abuse is the cause of many liver diseases, such as steatosis, alcoholic steatohepatitis, fibrosis, cirrhosis, and, potentially, hepatocellular cancer. In this study, the effect of chronic alcohol exposure on rat liver mitochondria was investigated. We observed an ethanol-induced increase in sensitivity to calcium, changes in the level of protein kinase Akt and GSK-3β phosphorylation, an induction of the mitochondrial permeability transition pore (mPTP), and strong alterations in the expression of mPTP regulators. Moreover, we also showed an enhanced effect of PK11195 and PPIX, on the parameters of the mPTP opening in rat liver mitochondria (RLM) isolated from ethanol-treated rats compared to the RLM from control rats. We suggest that the results of this study could help elucidate the mechanisms of chronic ethanol action on the mitochondria and contribute to the development of new therapeutic strategies for treating the effects of ethanol-related diseases." @default.
- W3044303841 created "2020-07-29" @default.
- W3044303841 creator A5008309539 @default.
- W3044303841 creator A5026895094 @default.
- W3044303841 creator A5084322515 @default.
- W3044303841 date "2020-07-24" @default.
- W3044303841 modified "2023-10-13" @default.
- W3044303841 title "The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore" @default.
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- W3044303841 doi "https://doi.org/10.3390/cells9081774" @default.
- W3044303841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7463720" @default.
- W3044303841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32722345" @default.
- W3044303841 hasPublicationYear "2020" @default.
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