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- W3044333901 abstract "Dysregulation of long non-coding RNAs (lncRNAs) has been implicated in many cancer developments. Previous studies showed that lncRNA LINC00941 was aberrantly expressed in oral squamous cell carcinoma (OSCC). However, its role in OSCC development remains elusive. In this study, we demonstrated that in OSCC cells, EP300 activates LINC00941 transcription through up-regulating its promoter H3K27ac modification. Up-regulated LINC00941 in turn activates CAPRIN2 expression by looping to CAPRIN2 promoter. Functional assays suggest that both LINC00941 and CAPRIN2 play pivotal roles in promoting OSCC cell proliferation and colony formation. In vivo assay further confirmed the role of LINC00941 in promoting OSCC cell tumour formation. Lastly, we showed that the role of LINC00941 and CAPRIN2 in OSCC progression was mediated through activating the canonical WNT/β-catenin signaling pathway. Thus, LINC00941/CAPRIN2/ WNT/β-catenin signaling pathway provides new therapeutic targets for OSCC treatment." @default.
- W3044333901 created "2020-07-29" @default.
- W3044333901 creator A5001881392 @default.
- W3044333901 creator A5014646073 @default.
- W3044333901 creator A5056900069 @default.
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- W3044333901 date "2020-07-21" @default.
- W3044333901 modified "2023-10-15" @default.
- W3044333901 title "LINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β‐catenin signaling pathway" @default.
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- W3044333901 doi "https://doi.org/10.1111/jcmm.15667" @default.
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- W3044333901 hasPublicationYear "2020" @default.
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