FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044336517> ?p ?o ?g. }

• W3044336517 endingPage "141161" @default.
• W3044336517 startingPage "141161" @default.
• W3044336517 abstract "Polycyclic aromatic hydrocarbons (PAHs) are global contaminants of concern. Despite several decades of research, their mechanisms of toxicity are not very well understood. Early life stages of fish are particularly sensitive with the developing cardiac tissue being a main target of PAHs toxicity. The mechanisms of cardiotoxicity of the three widespread model polycyclic aromatic hydrocarbons (PAHs) retene, pyrene and phenanthrene were explored in rainbow trout (Oncorhynchus mykiss) early life stages. Newly hatched larvae were exposed to sublethal doses of each individual PAH causing no detectable morphometric alterations. Changes in the cardiac proteome and metabolome were assessed after 7 or 14 days of exposure to each PAH. Phase I and II enzymes regulated by the aryl hydrocarbon receptor were significantly induced by all PAHs, with retene being the most potent compound. Retene significantly altered the level of several proteins involved in key cardiac functions such as muscle contraction, cellular tight junctions or calcium homeostasis. Those findings were quite consistent with previous reports regarding the effects of retene on the cardiac transcriptome. Significant changes in proteins linked to iron and heme metabolism were observed following exposure to pyrene. While phenanthrene also altered the levels of several proteins in the cardiac tissue, no clear mechanisms or pathways could be highlighted. Due to high variability between samples, very few significant changes were detected in the cardiac metabolome overall. Slight but significant changes were still observed for pyrene and phenanthrene, suggesting possible effects on several energetic or signaling pathways. This study shows that early exposure to different PAHs can alter the expression of key proteins involved in the cardiac function, which could potentially affect negatively the fitness of the larvae and later of the juvenile fish." @default.
• W3044336517 created "2020-07-29" @default.
• W3044336517 creator A5002459676 @default.
• W3044336517 creator A5005329182 @default.
• W3044336517 creator A5023138310 @default.
• W3044336517 creator A5028047610 @default.
• W3044336517 creator A5028091116 @default.
• W3044336517 creator A5037916867 @default.
• W3044336517 creator A5067468665 @default.
• W3044336517 creator A5090922741 @default.
• W3044336517 date "2020-12-01" @default.
• W3044336517 modified "2023-10-14" @default.
• W3044336517 title "Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 2 – Proteomics and metabolomics" @default.
• W3044336517 cites W1450445246 @default.
• W3044336517 cites W1540016031 @default.
• W3044336517 cites W1691784839 @default.
• W3044336517 cites W1956354269 @default.
• W3044336517 cites W1963612766 @default.
• W3044336517 cites W1973622869 @default.
• W3044336517 cites W1976148478 @default.
• W3044336517 cites W1984750810 @default.
• W3044336517 cites W1985716327 @default.
• W3044336517 cites W1990131329 @default.
• W3044336517 cites W1994409908 @default.
• W3044336517 cites W1997602332 @default.
• W3044336517 cites W1998642782 @default.
• W3044336517 cites W2005501206 @default.
• W3044336517 cites W2006900120 @default.
• W3044336517 cites W2007562250 @default.
• W3044336517 cites W2007741394 @default.
• W3044336517 cites W2008485110 @default.
• W3044336517 cites W2012109162 @default.
• W3044336517 cites W2016320904 @default.
• W3044336517 cites W2016918522 @default.
• W3044336517 cites W2020822758 @default.
• W3044336517 cites W2023089171 @default.
• W3044336517 cites W2026235728 @default.
• W3044336517 cites W2026343686 @default.
• W3044336517 cites W2032647451 @default.
• W3044336517 cites W2035789831 @default.
• W3044336517 cites W2036321220 @default.
• W3044336517 cites W2042185075 @default.
• W3044336517 cites W2044519235 @default.
• W3044336517 cites W2046451933 @default.
• W3044336517 cites W2046623154 @default.
• W3044336517 cites W2047307490 @default.
• W3044336517 cites W2049275579 @default.
• W3044336517 cites W2049892812 @default.
• W3044336517 cites W2051288838 @default.
• W3044336517 cites W2056639242 @default.
• W3044336517 cites W2057471658 @default.
• W3044336517 cites W2070617809 @default.
• W3044336517 cites W2071573213 @default.
• W3044336517 cites W2072833403 @default.
• W3044336517 cites W2079657198 @default.
• W3044336517 cites W2080667675 @default.
• W3044336517 cites W2080752012 @default.
• W3044336517 cites W2084229506 @default.
• W3044336517 cites W2086687109 @default.
• W3044336517 cites W2087801729 @default.
• W3044336517 cites W2092065899 @default.
• W3044336517 cites W2092495955 @default.
• W3044336517 cites W2093428806 @default.
• W3044336517 cites W2093745817 @default.
• W3044336517 cites W2094539821 @default.
• W3044336517 cites W2098636925 @default.
• W3044336517 cites W2104790506 @default.
• W3044336517 cites W2106839391 @default.
• W3044336517 cites W2110585976 @default.
• W3044336517 cites W2122244280 @default.
• W3044336517 cites W2131193610 @default.
• W3044336517 cites W2165569721 @default.
• W3044336517 cites W2174721344 @default.
• W3044336517 cites W2177423030 @default.
• W3044336517 cites W2339806509 @default.
• W3044336517 cites W2471426571 @default.
• W3044336517 cites W2520673124 @default.
• W3044336517 cites W2549436143 @default.
• W3044336517 cites W2567146478 @default.
• W3044336517 cites W2584770468 @default.
• W3044336517 cites W2602096984 @default.
• W3044336517 cites W2605241186 @default.
• W3044336517 cites W2615098380 @default.
• W3044336517 cites W2616232958 @default.
• W3044336517 cites W2763700933 @default.
• W3044336517 cites W2787897791 @default.
• W3044336517 cites W2796295819 @default.
• W3044336517 cites W2806016692 @default.
• W3044336517 cites W2886356122 @default.
• W3044336517 cites W2905675459 @default.
• W3044336517 cites W2920470886 @default.
• W3044336517 cites W2944833616 @default.
• W3044336517 cites W2944970953 @default.
• W3044336517 cites W2952143471 @default.
• W3044336517 cites W3044230951 @default.
• W3044336517 cites W55016974 @default.
• W3044336517 doi "https://doi.org/10.1016/j.scitotenv.2020.141161" @default.
• W3044336517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32750582" @default.

• next