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- W3044340065 abstract "Abstract The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identified as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identified miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets." @default.
- W3044340065 created "2020-07-29" @default.
- W3044340065 creator A5003915926 @default.
- W3044340065 creator A5031062047 @default.
- W3044340065 creator A5049766753 @default.
- W3044340065 creator A5085095503 @default.
- W3044340065 date "2020-07-23" @default.
- W3044340065 modified "2023-09-26" @default.
- W3044340065 title "Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis" @default.
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- W3044340065 doi "https://doi.org/10.1038/s41598-020-69290-7" @default.
- W3044340065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7378055" @default.
- W3044340065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32704070" @default.
- W3044340065 hasPublicationYear "2020" @default.
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