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- W3044345944 startingPage "108254" @default.
- W3044345944 abstract "Emerging evidence suggests that females are less sensitive than males to the effects of kappa opioid receptor (KOR) ligands across multiple behavioral measures. The effects of the KOR agonist U50,488 and the KOR antagonist aticaprant were assessed on nest building behavior, an ethologically relevant indicator of overall well-being and affect, in adult male and female C57BL/6J mice. Females required a higher dose of U50,488 to suppress nesting, and a higher dose of aticaprant to restore U50,488-induced impairment of nesting. Females also required a higher dose of aticaprant to decrease immobility scores in the forced swim test. Pretreatment with the estrogen receptor modulator tamoxifen, at a dose which blocked estrogen receptors, augmented the effect of U50,488 on nesting in female mice, suggesting that estrogen receptors play a key role in attenuating the effects of KOR ligands in female mice. Together, these results suggest that females are less sensitive to KOR mediation, requiring a higher dose to achieve comparable results to males. This behavioral sensitivity, as measured by nesting, may be mediated by estrogen receptors. Together these studies highlight the importance of comparing sex differences in response to KOR regulation on behaviors related to affective states." @default.
- W3044345944 created "2020-07-29" @default.
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- W3044345944 date "2020-10-01" @default.
- W3044345944 modified "2023-10-18" @default.
- W3044345944 title "Sex differences in the modulation of mouse nest building behavior by kappa opioid receptor signaling" @default.
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- W3044345944 cites W1971846039 @default.
- W3044345944 cites W1972989195 @default.
- W3044345944 cites W1979031324 @default.
- W3044345944 cites W1980915383 @default.
- W3044345944 cites W1989359858 @default.
- W3044345944 cites W1990696516 @default.
- W3044345944 cites W1996236128 @default.
- W3044345944 cites W2002233087 @default.
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- W3044345944 cites W2011645297 @default.
- W3044345944 cites W2017570888 @default.
- W3044345944 cites W2017876257 @default.
- W3044345944 cites W2017930909 @default.
- W3044345944 cites W2023882909 @default.
- W3044345944 cites W2027618182 @default.
- W3044345944 cites W2028084760 @default.
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- W3044345944 cites W2032322073 @default.
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- W3044345944 doi "https://doi.org/10.1016/j.neuropharm.2020.108254" @default.
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