Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044370924> ?p ?o ?g. }
- W3044370924 endingPage "608" @default.
- W3044370924 startingPage "598" @default.
- W3044370924 abstract "Abstract Context The characteristics of catecholamine-secreting pheochromocytomas have been well studied. However, less is known about the characteristics, management and outcome in patients with ectopic adrenocorticotropic hormone (ACTH) and/or corticotrophin-releasing hormone (CRH)-secreting pheochromocytomas. Objective To review the characteristics and outcomes of ACTH- and/or CRH-secreting pheochromocytomas. Data Source A systematic search of PubMed/MEDLINE and Web of Science, identifying relevant reports published up to 10 February 2020. Study Selection Original articles, including case reports and case series, reporting individual patient data from patients with ACTH- and/or CRH-secreting pheochromocytomas. Data extraction Information on sex, age, symptoms at presentation, comorbidities, biochemistry, imaging, histopathology, and outcomes was extracted. Data Synthesis We identified 91 articles reporting on 99 cases of ACTH- and/or CRH-secreting pheochromocytomas (CRH-secreting n = 4). Median age at diagnosis was 49 years (interquartile range 38-59.5) with a 2:1 female to male ratio. Most patients presented with clinical Cushing syndrome (n = 79; 81%), hypertension (n = 87; 93%), and/or diabetes (n = 50; 54%). Blood pressure, glucose control, and biochemical parameters improved in the vast majority of patients postoperatively. Infections were the most common complication. Most cases (n = 70, 88%) with reported long-term outcome survived to publication (median follow-up 6 months). Conclusion Ectopic ACTH- and/or CRH-secreting pheochromocytoma should be considered in patients presenting with ACTH-dependent Cushing syndrome and adrenal mass. Despite the challenge in diagnosis, patient outcomes appear favorable." @default.
- W3044370924 created "2020-07-29" @default.
- W3044370924 creator A5023753830 @default.
- W3044370924 creator A5027438217 @default.
- W3044370924 creator A5051232498 @default.
- W3044370924 creator A5061952775 @default.
- W3044370924 date "2020-07-25" @default.
- W3044370924 modified "2023-10-14" @default.
- W3044370924 title "Ectopic ACTH- and/or CRH-Producing Pheochromocytomas" @default.
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