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• W3044381627 abstract "Unlike bone tissue, little progress has been made regarding cartilage regeneration, and many challenges remain . Furthermore, the key roles of cartilage lesion caused by traumas, focal lesion, or articular overstress remain unclear. Traumatic injuries to the meniscus as well as its degeneration are important risk factors for long-term joint dysfunction, degenerative joint lesions, and knee OA a chronic joint disease characterized by degeneration of articular cartilage and hyperosteogeny . Due to the limited inherent self-repair capacity of cartilage lesion, the Biomaterial drug-nanomedicine is considered to be a promising alternative. Therefore, it is important to elucidate the gene potential regeneration mechanisms and discover novel precise medication, which are identified through this study to investigate their function and role in pathogenesis. Methods: We downloaded the mRNA microarray statistics GSE117999, involving paired cartilage lesion tissue samples from 12 OA patients and 12 patients from a control group. First, we analysed these statistics to recognize the differentially expressed genes (DEGs). We then exposed the gene ontology (GO) annotation and the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses for these DEGs. Protein- protein interaction (PPI) networks were then constructed, from which we attained eight significant genes after a functional interaction analysis. Finally, we identified a potential nanomedicine attained from this assay set, using a wide range of inhibitor information archived in the Search Tool for the Retrieval of Interacting Genes (STRING) database. 66 DEGs were identified with our standards for meaning (adjusted P- value < 0.01, |log2 - FC| ≥1.2). Furthermore, We identified eight hub genes and one potential nanomedicine - Selenocysteine based on these integrative data. We identified eight hub genes that could work as prospective biomarkers for the diagnostic and biomaterial drug treatment of cartilage lesion, involving the novel genes CAMP, DEFA3, TOLLIP, HLA-DQA2, SLC38A6, SLC3A1, FAM20A and ANO8. Meanwhile, these genes were mainly associated with immune response, immune mediator induction and cell chemotaxis. Significant support is provided for obtaining a series of novel gene targets, and we identify potential mechanisms for cartilage regeneration and final nanomedicine immunotherapy in regenerative medicine." @default.
• W3044381627 created "2020-07-29" @default.
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• W3044381627 date "2020-07-24" @default.
• W3044381627 modified "2023-10-14" @default.
• W3044381627 title "Discovery of Selenocysteine as a Potential Nanomedicine Promotes Cartilage Regeneration With Enhanced Immune Response by Text Mining and Biomedical Databases" @default.
• W3044381627 cites W1568921412 @default.
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• W3044381627 cites W1965857062 @default.
• W3044381627 cites W1970064397 @default.
• W3044381627 cites W1971651108 @default.
• W3044381627 cites W2000624125 @default.
• W3044381627 cites W2003943898 @default.
• W3044381627 cites W2007227328 @default.
• W3044381627 cites W2015216944 @default.
• W3044381627 cites W2015601552 @default.
• W3044381627 cites W2019150689 @default.
• W3044381627 cites W2021176581 @default.
• W3044381627 cites W2043639065 @default.
• W3044381627 cites W2044920905 @default.
• W3044381627 cites W2060306551 @default.
• W3044381627 cites W2061819648 @default.
• W3044381627 cites W2065562721 @default.
• W3044381627 cites W2096676560 @default.
• W3044381627 cites W2118258530 @default.
• W3044381627 cites W2122683221 @default.
• W3044381627 cites W2132527486 @default.
• W3044381627 cites W2146512944 @default.
• W3044381627 cites W2147852098 @default.
• W3044381627 cites W2154078483 @default.
• W3044381627 cites W2183346825 @default.
• W3044381627 cites W2183362679 @default.
• W3044381627 cites W2276834492 @default.
• W3044381627 cites W2396464958 @default.
• W3044381627 cites W2508611306 @default.
• W3044381627 cites W2547565465 @default.
• W3044381627 cites W2555713582 @default.
• W3044381627 cites W2559588208 @default.
• W3044381627 cites W2569472942 @default.
• W3044381627 cites W2604808360 @default.
• W3044381627 cites W2611032097 @default.
• W3044381627 cites W2616346928 @default.
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• W3044381627 cites W2801652044 @default.
• W3044381627 cites W2801866793 @default.
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• W3044381627 cites W2913033120 @default.
• W3044381627 cites W2920449326 @default.
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• W3044381627 cites W2946370455 @default.
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• W3044381627 doi "https://doi.org/10.3389/fphar.2020.01138" @default.
• W3044381627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7394085" @default.
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• W3044381627 hasPublicationYear "2020" @default.
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