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• W3044388081 abstract "Abstract Human immunodeficiency virus has been a leading cause of morbidity in the last three decades. The introduction of Highly active antiretroviral therapy (HAART) has controlled the disease to a large extent, but an effective cure is still not achieved. Clustered Regularly interspaced short palindromic repeats (CRISPR) and associated Cas9 system aims at a cure rather than control of HIV. CRISPR-Cas9 consists of a guide RNA that has a sequence complementary to CCR-5, a gene present on the white blood cells. The two binds together and are recognized by the Cas9 nuclease. Cas9 has a scissor like action, it cuts the complex at the target site and inactivates it. Current approaches using CRISPR-Cas 9 aims at targeting CCR-5 gene to confer resistance to HIV infection. In this mini-review, we introduce this technology to general physicians and inform about its current and future applications in treating HIV-1 infection." @default.
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• W3044388081 date "2020-07-01" @default.
• W3044388081 modified "2023-09-22" @default.
• W3044388081 title "HIV: Can gene editing provide a cure for HIV?" @default.
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• W3044388081 doi "https://doi.org/10.1016/j.cmrp.2020.07.012" @default.
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