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- W3044393460 abstract "Aim: To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice. Methods: C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra -/- mice were also evaluated. Results: All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra -/- mice succumbed to infection within 16 days. Conclusion: This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae." @default.
- W3044393460 created "2020-07-29" @default.
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- W3044393460 date "2020-06-01" @default.
- W3044393460 modified "2023-10-02" @default.
- W3044393460 title "<i>Rhizopus</i>-host interplay of disseminated mucormycosis in immunocompetent mice" @default.
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- W3044393460 doi "https://doi.org/10.2217/fmb-2019-0246" @default.
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