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- W3044401433 endingPage "733" @default.
- W3044401433 startingPage "713" @default.
- W3044401433 abstract "Most methanogenic archaea use the rudimentary hydrogenotrophic pathway—from CO 2 and H 2 to methane—as the terminal step of microbial biomass degradation in anoxic habitats. The barely exergonic process that just conserves sufficient energy for a modest lifestyle involves chemically challenging reactions catalyzed by complex enzyme machineries with unique metal-containing cofactors. The basic strategy of the methanogenic energy metabolism is to covalently bind C 1 species to the C 1 carriers methanofuran, tetrahydromethanopterin, and coenzyme M at different oxidation states. The four reduction reactions from CO 2 to methane involve one molybdopterin-based two-electron reduction, two coenzyme F 420 –based hydride transfers, and one coenzyme F 430 –based radical process. For energy conservation, one ion-gradient-forming methyl transfer reaction is sufficient, albeit supported by a sophisticated energy-coupling process termed flavin-based electron bifurcation for driving the endergonic CO 2 reduction and fixation. Here, we review the knowledge about the structure-based catalytic mechanism of each enzyme of hydrogenotrophic methanogenesis." @default.
- W3044401433 created "2020-07-29" @default.
- W3044401433 creator A5011113766 @default.
- W3044401433 creator A5024397298 @default.
- W3044401433 creator A5065545180 @default.
- W3044401433 creator A5082829914 @default.
- W3044401433 date "2020-09-08" @default.
- W3044401433 modified "2023-10-14" @default.
- W3044401433 title "Structural Basis of Hydrogenotrophic Methanogenesis" @default.
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