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• W3044401827 abstract "Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres." @default.
• W3044401827 created "2020-07-29" @default.
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• W3044401827 date "2020-07-27" @default.
• W3044401827 modified "2023-10-16" @default.
• W3044401827 title "Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19" @default.
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• W3044401827 doi "https://doi.org/10.1038/s41541-020-00221-3" @default.
• W3044401827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385486" @default.
• W3044401827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33580068" @default.
• W3044401827 hasPublicationYear "2020" @default.
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