FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044401979> ?p ?o ?g. }

• W3044401979 endingPage "381" @default.
• W3044401979 startingPage "366" @default.
• W3044401979 abstract "Background ICU survivors can experience both cognitive dysfunction and persistent sleep disturbances after hospitalization. Sleep disturbances have been linked with cognitive impairment in various patient populations, and the apolipoprotein E (APOE) genotype has been linked to sleep-related impairments in cognition. Research Question Is there an association between sleep, long-term cognition, and APOE status in ICU survivors? Study Design and Methods We enrolled 150 patients from five centers who had been mechanically ventilated for at least 3 days; 102 patients survived to ICU discharge. Actigraphy and cognitive testing were undertaken at 7 days, 6 months, and 12 months after ICU discharge, and sleep duration, quality, and timing were estimated by actigraphy. APOE single nucleotide polymorphisms were assessed for each patient. Results Actigraphy-estimated sleep fragmentation, but not total sleep time or interdaily stability (estimate of circadian rhythmicity), was associated with worse cognitive impairment at 7 days of ICU discharge. No actigraphy-estimated variable of sleep estimation at 7 days post-ICU discharge predicted cognitive impairment or persistent sleep abnormalities at 6 and 12 months of follow-up in subsequently assessed survivors. Possessing the APOE ε4 allele was not significantly associated with sleep disturbances and its presence did not modify the risk of sleep-related cognitive impairment at follow-up. Interpretation Sleep fragmentation estimated by actigraphy was associated with worse cognitive performance in hospital, but not at later time intervals. Further research is needed to better delineate the relationship between persistent sleep disturbances and cognition in larger numbers of ICU survivors. Trial Registry ClinicalTrials.gov; No.: NCT02086877; URL: www.clinicaltrials.gov; ICU survivors can experience both cognitive dysfunction and persistent sleep disturbances after hospitalization. Sleep disturbances have been linked with cognitive impairment in various patient populations, and the apolipoprotein E (APOE) genotype has been linked to sleep-related impairments in cognition. Is there an association between sleep, long-term cognition, and APOE status in ICU survivors? We enrolled 150 patients from five centers who had been mechanically ventilated for at least 3 days; 102 patients survived to ICU discharge. Actigraphy and cognitive testing were undertaken at 7 days, 6 months, and 12 months after ICU discharge, and sleep duration, quality, and timing were estimated by actigraphy. APOE single nucleotide polymorphisms were assessed for each patient. Actigraphy-estimated sleep fragmentation, but not total sleep time or interdaily stability (estimate of circadian rhythmicity), was associated with worse cognitive impairment at 7 days of ICU discharge. No actigraphy-estimated variable of sleep estimation at 7 days post-ICU discharge predicted cognitive impairment or persistent sleep abnormalities at 6 and 12 months of follow-up in subsequently assessed survivors. Possessing the APOE ε4 allele was not significantly associated with sleep disturbances and its presence did not modify the risk of sleep-related cognitive impairment at follow-up. Sleep fragmentation estimated by actigraphy was associated with worse cognitive performance in hospital, but not at later time intervals. Further research is needed to better delineate the relationship between persistent sleep disturbances and cognition in larger numbers of ICU survivors. ClinicalTrials.gov; No.: NCT02086877; URL: www.clinicaltrials.gov; A Good Night’s Sleep After the ICU: Does Better Sleep Lead to Better Recovery After Critical Illness?CHESTVol. 159Issue 1PreviewFew things remain as elusive in medicine as understanding how to protect the human brain. Whereas there has been substantial clinical and scientific progress in other domains such as cardiovascular and cancer care, ways to concretely and systematically prevent cognitive decline remain undefined. Accordingly, as the medical care for critical illness becomes more advanced and more lives are saved, the short- and long-term neurocognitive consequences of an ICU stay are becoming increasingly apparent and important to address. Full-Text PDF" @default.
• W3044401979 created "2020-07-29" @default.
• W3044401979 creator A5000256626 @default.
• W3044401979 creator A5000833816 @default.
• W3044401979 creator A5001422220 @default.
• W3044401979 creator A5011364849 @default.
• W3044401979 creator A5040635626 @default.
• W3044401979 creator A5046059470 @default.
• W3044401979 creator A5081098059 @default.
• W3044401979 creator A5082185641 @default.
• W3044401979 creator A5089550922 @default.
• W3044401979 date "2021-01-01" @default.
• W3044401979 modified "2023-10-18" @default.
• W3044401979 title "Sleep Fragmentation and Cognitive Trajectories After Critical Illness" @default.
• W3044401979 cites W1277966809 @default.
• W3044401979 cites W1636066922 @default.
• W3044401979 cites W1771586933 @default.
• W3044401979 cites W1965738012 @default.
• W3044401979 cites W1973798645 @default.
• W3044401979 cites W1977711623 @default.
• W3044401979 cites W1983620103 @default.
• W3044401979 cites W1983988971 @default.
• W3044401979 cites W1993641530 @default.
• W3044401979 cites W1994384365 @default.
• W3044401979 cites W1995972463 @default.
• W3044401979 cites W1999631936 @default.
• W3044401979 cites W2004284087 @default.
• W3044401979 cites W2012677452 @default.
• W3044401979 cites W2014238635 @default.
• W3044401979 cites W2021427108 @default.
• W3044401979 cites W2022490794 @default.
• W3044401979 cites W2027412958 @default.
• W3044401979 cites W2033988957 @default.
• W3044401979 cites W2036362108 @default.
• W3044401979 cites W2038003980 @default.
• W3044401979 cites W2039344353 @default.
• W3044401979 cites W2043909860 @default.
• W3044401979 cites W2058120050 @default.
• W3044401979 cites W2063816205 @default.
• W3044401979 cites W2064115528 @default.
• W3044401979 cites W2066821552 @default.
• W3044401979 cites W2070847731 @default.
• W3044401979 cites W2080024848 @default.
• W3044401979 cites W2080512598 @default.
• W3044401979 cites W2080666011 @default.
• W3044401979 cites W2084450115 @default.
• W3044401979 cites W2090672265 @default.
• W3044401979 cites W2095527556 @default.
• W3044401979 cites W2097605210 @default.
• W3044401979 cites W2100582107 @default.
• W3044401979 cites W2102912706 @default.
• W3044401979 cites W2108485082 @default.
• W3044401979 cites W2113676328 @default.
• W3044401979 cites W2116201938 @default.
• W3044401979 cites W2116838188 @default.
• W3044401979 cites W2122300726 @default.
• W3044401979 cites W2133367784 @default.
• W3044401979 cites W2142255636 @default.
• W3044401979 cites W2142340137 @default.
• W3044401979 cites W2143955562 @default.
• W3044401979 cites W2144829518 @default.
• W3044401979 cites W2160385789 @default.
• W3044401979 cites W2164449928 @default.
• W3044401979 cites W2165071259 @default.
• W3044401979 cites W2171035998 @default.
• W3044401979 cites W2328610580 @default.
• W3044401979 cites W2346707803 @default.
• W3044401979 cites W2482717739 @default.
• W3044401979 cites W2552517833 @default.
• W3044401979 cites W2588086616 @default.
• W3044401979 cites W2619879339 @default.
• W3044401979 cites W2735877215 @default.
• W3044401979 cites W2754890392 @default.
• W3044401979 cites W2766216491 @default.
• W3044401979 cites W2769216997 @default.
• W3044401979 cites W2804411892 @default.
• W3044401979 cites W2890360678 @default.
• W3044401979 cites W2949280410 @default.
• W3044401979 cites W311306514 @default.
• W3044401979 cites W4294747801 @default.
• W3044401979 doi "https://doi.org/10.1016/j.chest.2020.07.036" @default.
• W3044401979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32717265" @default.
• W3044401979 hasPublicationYear "2021" @default.
• W3044401979 type Work @default.
• W3044401979 sameAs 3044401979 @default.
• W3044401979 citedByCount "18" @default.
• W3044401979 countsByYear W30444019792020 @default.
• W3044401979 countsByYear W30444019792021 @default.
• W3044401979 countsByYear W30444019792022 @default.
• W3044401979 countsByYear W30444019792023 @default.
• W3044401979 crossrefType "journal-article" @default.
• W3044401979 hasAuthorship W3044401979A5000256626 @default.
• W3044401979 hasAuthorship W3044401979A5000833816 @default.
• W3044401979 hasAuthorship W3044401979A5001422220 @default.
• W3044401979 hasAuthorship W3044401979A5011364849 @default.
• W3044401979 hasAuthorship W3044401979A5040635626 @default.
• W3044401979 hasAuthorship W3044401979A5046059470 @default.
• W3044401979 hasAuthorship W3044401979A5081098059 @default.

• next