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- W3044405565 abstract "Significance Animal NLRs form wheel-like structures called inflammasomes upon perception of pathogen-associated molecules. The induced proximity of the signaling domains at the center of the wheel is hypothesized to recruit caspases for the first step of immune signal transduction. We expressed a plant-animal NLR fusion to demonstrate that induced proximity of TIR signaling domains from plant NLRs is sufficient to activate plant immune signaling. This demonstrates that a signaling-competent inflammasome can be formed from known, minimal components. The intrinsic NADase activity of plant TIRs is necessary for immune signaling, but fusions to a bacterial or a mammalian TIR domain with NADase activity, which also lead to accumulation of NAD + hydrolysis products (e.g. cyclic ADP-ribose), were unable to activate immune signaling." @default.
- W3044405565 created "2020-07-29" @default.
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- W3044405565 date "2020-07-24" @default.
- W3044405565 modified "2023-10-05" @default.
- W3044405565 title "Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants" @default.
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- W3044405565 doi "https://doi.org/10.1073/pnas.2001185117" @default.
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