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• W3044430040 startingPage "1181" @default.
• W3044430040 abstract "Abstract A small subset of cutaneous melanomas harbor oncogenic gene fusions, which could potentially serve as therapeutic targets for patients with advanced disease as novel therapies are developed. Fusions involving RAF1 are exceedingly rare in melanocytic neoplasms, occurring in less than 1% of melanomas, and usually arise in tumors that are wild type for BRAF , NRAS , and NF1 . We describe herein a case of acral melanoma with two satellite metastases and sentinel lymph node involvement. The melanoma had a concomitant KIT variant and LRRFIP2‐RAF1 fusion. This constellation of molecular findings has not been reported previously in melanoma. We review the existing literature on melanocytic neoplasms with RAF1 fusions and discuss the potential clinical implications of this genetic event." @default.
• W3044430040 created "2020-07-29" @default.
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• W3044430040 date "2020-09-07" @default.
• W3044430040 modified "2023-10-10" @default.
• W3044430040 title "Novel <scp><i>LRRFIP2‐RAF1</i></scp> fusion identified in an acral melanoma: A review of the literature on melanocytic proliferations with <scp><i>RAF1</i></scp> fusions and the potential therapeutic implications" @default.
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• W3044430040 doi "https://doi.org/10.1111/cup.13817" @default.
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