Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044450240> ?p ?o ?g. }
- W3044450240 abstract "Group A Streptococcus (GAS) is a strict human pathogen causing more than 700 million infections globally each year. The majority of the disease-causing GAS are encapsulated, which greatly guarantees survival and dissemination in the host. Emergence of the capsule-negative GAS, such as M4 GAS, in recent epidemiologic surveillance alarms the necessity to elucidate the virulence determinants of these pathogens. Here, we found that M4 pili play an important role in promoting M4 GAS adherence and cytotoxicity to human pharyngeal epithelial cells and keratinocytes. The same molecule also significantly enhanced M4 GAS survival and replication in human whole blood and experimental murine infection. T4 antigen, which composes the backbone of M4 pili, was able to sequester the very abundant serum protein haptoglobin to further confer M4 GAS resistance to antibacterial substances released by neutrophils and platelets." @default.
- W3044450240 created "2020-07-29" @default.
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- W3044450240 date "2020-08-25" @default.
- W3044450240 modified "2023-10-13" @default.
- W3044450240 title "T4 Pili Promote Colonization and Immune Evasion Phenotypes of Nonencapsulated M4 Streptococcus pyogenes" @default.
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- W3044450240 doi "https://doi.org/10.1128/mbio.01580-20" @default.
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