FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044450793> ?p ?o ?g. }

• W3044450793 endingPage "10366" @default.
• W3044450793 startingPage "10356" @default.
• W3044450793 abstract "Abstract Unresolved inflammation maintained by release of danger‐associated molecular patterns, particularly high‐mobility group box‐1 (HMGB1), is crucial for hepatocellular carcinoma (HCC) pathogenesis. To further characterize interactions between leucocytes and necrotic cancerous tissue, a cellular model of necroinflammation was studied in which murine Raw 264.7 macrophages or primary splenocytes were exposed to necrotic lysates (N‐lys) of murine hepatoma cells or primary hepatocytes. In comparison to those derived from primary hepatocytes, N‐lys from hepatoma cells were highly active—inducing in macrophages efficient expression of inflammatory cytokines like C‐X‐C motif ligand‐2 , tumor necrosis factor‐α, interleukin (IL)‐6 and IL‐23‐p19. This activity associated with higher levels of HMGB1 in hepatoma cells and was curbed by pharmacological blockage of the receptor for advanced glycation end product (RAGE)/HMGB1 axis or the mitogen‐activated protein kinases ERK1/2 pathway. Analysis of murine splenocytes furthermore demonstrated that N‐lys did not comprise of functionally relevant amounts of TLR4 agonists. Finally, N‐lys derived from hepatoma cells supported inflammatory splenic Th17 and Th1 polarization as detected by IL‐17, IL‐22 or interferon‐γ production. Altogether, a straightforward applicable model was established which allows for biochemical characterization of immunoregulation by HCC necrosis in cell culture. Data presented indicate a remarkably inflammatory capacity of necrotic hepatoma cells that, at least partly, depends on the RAGE/HMGB1 axis and may shape immunological properties of the HCC microenvironment." @default.
• W3044450793 created "2020-07-29" @default.
• W3044450793 creator A5054077321 @default.
• W3044450793 creator A5063893851 @default.
• W3044450793 creator A5074909982 @default.
• W3044450793 creator A5080016791 @default.
• W3044450793 creator A5083512823 @default.
• W3044450793 date "2020-07-22" @default.
• W3044450793 modified "2023-10-16" @default.
• W3044450793 title "A murine cellular model of necroinflammation displays RAGE‐dependent cytokine induction that connects to hepatoma cell injury" @default.
• W3044450793 cites W1952051806 @default.
• W3044450793 cites W1964182229 @default.
• W3044450793 cites W1964704428 @default.
• W3044450793 cites W1969981758 @default.
• W3044450793 cites W1974730356 @default.
• W3044450793 cites W2005033167 @default.
• W3044450793 cites W2014830013 @default.
• W3044450793 cites W2018653121 @default.
• W3044450793 cites W2022969414 @default.
• W3044450793 cites W2025575974 @default.
• W3044450793 cites W2034594119 @default.
• W3044450793 cites W2038972133 @default.
• W3044450793 cites W2052308581 @default.
• W3044450793 cites W2059478253 @default.
• W3044450793 cites W2059944604 @default.
• W3044450793 cites W2060274331 @default.
• W3044450793 cites W2064813814 @default.
• W3044450793 cites W2071044885 @default.
• W3044450793 cites W2071237104 @default.
• W3044450793 cites W2079140578 @default.
• W3044450793 cites W2080998956 @default.
• W3044450793 cites W2086146050 @default.
• W3044450793 cites W2092800788 @default.
• W3044450793 cites W2102831728 @default.
• W3044450793 cites W2104389740 @default.
• W3044450793 cites W2106644629 @default.
• W3044450793 cites W2107718568 @default.
• W3044450793 cites W2108517168 @default.
• W3044450793 cites W2109624315 @default.
• W3044450793 cites W2138954897 @default.
• W3044450793 cites W2142225943 @default.
• W3044450793 cites W2149003918 @default.
• W3044450793 cites W2342512212 @default.
• W3044450793 cites W2461097392 @default.
• W3044450793 cites W2515730340 @default.
• W3044450793 cites W2526447978 @default.
• W3044450793 cites W2530951717 @default.
• W3044450793 cites W2532470837 @default.
• W3044450793 cites W2550399881 @default.
• W3044450793 cites W2610721624 @default.
• W3044450793 cites W2611795015 @default.
• W3044450793 cites W2616559215 @default.
• W3044450793 cites W2617096708 @default.
• W3044450793 cites W2736181072 @default.
• W3044450793 cites W2767678580 @default.
• W3044450793 cites W2785327608 @default.
• W3044450793 cites W2790813184 @default.
• W3044450793 cites W2792376809 @default.
• W3044450793 cites W2792777645 @default.
• W3044450793 cites W2890644813 @default.
• W3044450793 cites W2893742563 @default.
• W3044450793 cites W2894833630 @default.
• W3044450793 cites W2901245093 @default.
• W3044450793 cites W2906095458 @default.
• W3044450793 cites W2918877774 @default.
• W3044450793 cites W2947752714 @default.
• W3044450793 cites W2965704790 @default.
• W3044450793 cites W2968805786 @default.
• W3044450793 doi "https://doi.org/10.1111/jcmm.15649" @default.
• W3044450793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7521286" @default.
• W3044450793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32697038" @default.
• W3044450793 hasPublicationYear "2020" @default.
• W3044450793 type Work @default.
• W3044450793 sameAs 3044450793 @default.
• W3044450793 citedByCount "2" @default.
• W3044450793 countsByYear W30444507932021 @default.
• W3044450793 countsByYear W30444507932023 @default.
• W3044450793 crossrefType "journal-article" @default.
• W3044450793 hasAuthorship W3044450793A5054077321 @default.
• W3044450793 hasAuthorship W3044450793A5063893851 @default.
• W3044450793 hasAuthorship W3044450793A5074909982 @default.
• W3044450793 hasAuthorship W3044450793A5080016791 @default.
• W3044450793 hasAuthorship W3044450793A5083512823 @default.
• W3044450793 hasBestOaLocation W30444507931 @default.
• W3044450793 hasConcept C153911025 @default.
• W3044450793 hasConcept C159654299 @default.
• W3044450793 hasConcept C169760540 @default.
• W3044450793 hasConcept C17991360 @default.
• W3044450793 hasConcept C185592680 @default.
• W3044450793 hasConcept C189976730 @default.
• W3044450793 hasConcept C203014093 @default.
• W3044450793 hasConcept C2775975398 @default.
• W3044450793 hasConcept C2776178377 @default.
• W3044450793 hasConcept C2776914184 @default.
• W3044450793 hasConcept C2778690821 @default.
• W3044450793 hasConcept C2778857457 @default.
• W3044450793 hasConcept C2780545709 @default.
• W3044450793 hasConcept C502942594 @default.

• next