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- W3044457617 abstract "Objective To study the effect of lipopolysaccharide (LPS) on normal skin tissues (NS)-derived fibroblasts (NSFs) and the formation of hypertrophic scar (HS). Methods HSs and the corresponding NS tissues were sampled from the patients who underwent surgical excision at Xijing Hospital from November 2017 to November 2018. The characteristics of HSs and HSFs were identified by HE and Masson staining, immunohistochemistry/immunocytochemistry, real time quantitative PCR (RTqPCR), Western blotting and electron microscopy in scar formation cell models and mouse wound healing models. Results Thestaining results showed that the number of fibroblasts, level of extracullar matrix (ECM) proteins (ColⅠ, ColⅢ, and α-SMA) in HS were significantly higher than those in NS (P＜0.05). The mRNA and protein expression levels of ColⅠ, ColⅢ and α-SMA in HS/HSFs were significantly higher than those in NS/NSFs (P＜0.05). LPS could significantly increase the expression of Col Ⅰ, Col Ⅲ and α-SMA in NSFs, and the result was similar to those in HSFs (P＜0.05). The endoplasmic reticulum was normal and regulated in NSFs, but it was swollen and unregulated in LPS-stimulated NSFs and HSFs. After injection of LPS, the mice showed delayed wound healing and obvious scarring. Conclusions LPS can change the ultrastructure of endoplasmic reticulum, increase the expression of fibrotic proteins (e.g. ColⅠ, ColⅢ and α-SMA), lead to the accumulation of ECM proteins and the transformation of fibroblasts, and finally form HS.DOI: 10.11855/j.issn.0577-7402.2020.06.05" @default.
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- W3044457617 date "2020-06-28" @default.
- W3044457617 modified "2023-10-01" @default.
- W3044457617 title "Effects of lipopolysaccharide on expression of fibrosis-related factors in dermal fibroblast and hypertrophic scar formation" @default.
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