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- W3044466678 endingPage "1056" @default.
- W3044466678 startingPage "1043" @default.
- W3044466678 abstract "Age-related macular degeneration (AMD) is a progressive degenerative disease that is the leading cause of vision loss in the elderly population. Degeneration/dysregulation of the retinal pigment epithelium (RPE), a supportive monolayer of cells underlying the photoreceptors, is commonly seen in patients with AMD. While treatment exists for the neovascular/wet form of AMD, there is currently no cure for the non-exudative/dry form of AMD, making it imperative to understand the pathogenesis of this disease. Although our understanding of the aetiology of AMD has increased over the years, the underlying disease mechanism has not yet been identified, mainly due to the multifactorial nature of this disease. Herein, we review some of the commonly proposed degeneration pathways of RPE cells and their role in the pathogenesis of AMD; including activation of the complement cascade, oxidative stress-induced cell death mechanisms, dysfunctional mitochondria and the role of crystallins in AMD disease progression." @default.
- W3044466678 created "2020-07-29" @default.
- W3044466678 creator A5015360109 @default.
- W3044466678 creator A5017841563 @default.
- W3044466678 creator A5067778358 @default.
- W3044466678 creator A5089508620 @default.
- W3044466678 date "2020-08-17" @default.
- W3044466678 modified "2023-10-16" @default.
- W3044466678 title "Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms" @default.
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