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- W3044476032 abstract "• Intraperitoneal administration of LPS leads to neuroinflammation in the brain cortex. • Cytochrome P450 2J3 levels are down-regulated in the cortex during neuroinflammation. • Cytochrome P450 2C11 levels are down-regulated in the cortex during neuroinflammation. • Neuroinflammation decreases CYP levels and they are restored during resolution. Cytochrome P450 (CYP) epoxygenases have been considered the main producers of epoxyeicosatrienoic acids (EETs) through the oxidation of arachidonic acid (AA). EETs display various biological properties, notably their powerful anti-inflammatory activities. In the brain, EETs have proven to be neuroprotective and to improve neuroinflammation. However, it is known that inflammation could modify CYP expression. We have previously reported that an inflammatory process in astrocytes is able to down-regulate CYP2J3 and CYP2C11 mRNA, protein levels, and activity (Navarro-Mabarak et al., 2019). In this work, we evaluated the effect of neuroinflammation in protein expression of CYP epoxygenases in the brain. Neuroinflammation was induced by the intraperitoneal administration of LPS (1 mg/kg) to male Wistar rats and was corroborated by IL-6, GFAP, and Iba-1 protein levels in the cortex over time. CYP2J3 and CYP2C11 protein levels were also evaluated in the cortex after 6, 12, 24, 48, and 72 h of LPS treatment. Our results show for the first time that neuroinflammation is able to downregulate CYP2J3 and CYP2C11 protein expression in the brain cortex." @default.
- W3044476032 created "2020-07-29" @default.
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- W3044476032 date "2020-10-01" @default.
- W3044476032 modified "2023-10-14" @default.
- W3044476032 title "Neuroinflammation is able to downregulate cytochrome P450 epoxygenases 2J3 and 2C11 in the rat brain" @default.
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- W3044476032 doi "https://doi.org/10.1016/j.brainresbull.2020.07.016" @default.
- W3044476032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32707261" @default.
- W3044476032 hasPublicationYear "2020" @default.
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