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- W3044481517 endingPage "e3000561" @default.
- W3044481517 startingPage "e3000561" @default.
- W3044481517 abstract "Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood. Nanog is known to play a central role for maintenance of the pluripotency and maternal -zygotic transition (MZT). Here, we reveal a novel role of Nanog as a strong repressor of maternal β-catenin signaling to safeguard the embryo against hyperactivation of maternal β-catenin activity and hyperdorsalization. In zebrafish, knockdown of nanog at different levels led to either posteriorization or dorsalization, mimicking zygotic or maternal activation of Wnt/β-catenin activities, and the maternal zygotic mutant of nanog (MZnanog) showed strong activation of maternal β-catenin activity and hyperdorsalization. Although a constitutive activator-type Nanog (Vp16-Nanog, lacking the N terminal) perfectly rescued the MZT defects of MZnanog, it did not rescue the phenotypes resulting from β-catenin signaling activation. Mechanistically, the N terminal of Nanog directly interacts with T-cell factor (TCF) and interferes with the binding of β-catenin to TCF, thereby attenuating the transcriptional activity of β-catenin. Therefore, our study establishes a novel role for Nanog in repressing maternal β-catenin activity and demonstrates a transcriptional switch between β-catenin/TCF and Nanog/TCF complexes, which safeguards the embryo from global activation of maternal β-catenin activity." @default.
- W3044481517 created "2020-07-29" @default.
- W3044481517 creator A5017864600 @default.
- W3044481517 creator A5036576518 @default.
- W3044481517 creator A5054754027 @default.
- W3044481517 creator A5058040690 @default.
- W3044481517 creator A5068103864 @default.
- W3044481517 creator A5074118482 @default.
- W3044481517 creator A5090171905 @default.
- W3044481517 date "2020-07-23" @default.
- W3044481517 modified "2023-10-16" @default.
- W3044481517 title "Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors" @default.
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