FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044486631> ?p ?o ?g. }

• W3044486631 endingPage "4425" @default.
• W3044486631 startingPage "4414" @default.
• W3044486631 abstract "Abstract The respective antitumoral and protumoral roles of M1 and M2 tumor-associated macrophages (TAM) typify the complexity of macrophage function in cancer. In lung cancer, density and topology of distinct TAM phenotypes at the tumor center (TC) versus the invasive margin (IM) are largely unknown. Here, we investigated TAM subtype density and distribution between TC and IM in human lung cancer and TAM associations with overall survival. Macrophages isolated from adjacent nontumor tissue (NM), the TC (TC-TAM), and the IM (IM-TAM) were analyzed with RNA-sequencing (RNA-seq). Lung tumor tissue microarrays from 104 patient samples were constructed. M1 and M2 TAMs were identified using multiplex immunofluorescence staining and a tumor cell-TAM proximity analysis was performed. RNA-seq identified marked differences among NM, TC-TAM, and IM-TAM. On the basis of a panel of five selected markers (CD68, IL12, CCR7, CD163, and ALOX15), M2 predominance over M1 and M2 proximity to tumor cells was observed, especially at IM. Tumor cell proximity to TAM was linked with tumor cell survival and hypoxia was associated with accumulation of M2 TAM. Notably, lower density of M1 TC-TAM and higher proximity of tumor cells to M2 IM-TAM or lower proximity to M1 IM-TAM were linked with poor survival. In addition, three novel molecules (UBXN4, MFSD12, and ACTR6) from RNA-seq served as potential prognostic markers for lung cancer, and M2 predominance and juxtaposition of M2 TAM near tumor cells were associated with poor survival. Together, our results reveal the marked heterogeneity of TAM populations in different tumor regions, with M2 TAM predominance, particularly at IM. Significance: This study underlines the significance of the density, spatial distribution, and gene expression of TAM phenotypes as prognostic factors for overall survival in lung cancer." @default.
• W3044486631 created "2020-07-29" @default.
• W3044486631 creator A5016511599 @default.
• W3044486631 creator A5032227105 @default.
• W3044486631 creator A5036241222 @default.
• W3044486631 creator A5052349036 @default.
• W3044486631 creator A5053291675 @default.
• W3044486631 creator A5054116239 @default.
• W3044486631 creator A5058734088 @default.
• W3044486631 creator A5059087023 @default.
• W3044486631 creator A5067057792 @default.
• W3044486631 creator A5067410182 @default.
• W3044486631 creator A5090020095 @default.
• W3044486631 date "2020-10-15" @default.
• W3044486631 modified "2023-10-14" @default.
• W3044486631 title "Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non–Small Cell Lung Carcinoma" @default.
• W3044486631 cites W1107917109 @default.
• W3044486631 cites W1550280299 @default.
• W3044486631 cites W1593047235 @default.
• W3044486631 cites W1981876938 @default.
• W3044486631 cites W1989327041 @default.
• W3044486631 cites W1996083799 @default.
• W3044486631 cites W1997881977 @default.
• W3044486631 cites W2023057260 @default.
• W3044486631 cites W2025456523 @default.
• W3044486631 cites W2037150116 @default.
• W3044486631 cites W2038310444 @default.
• W3044486631 cites W2049491375 @default.
• W3044486631 cites W2097581069 @default.
• W3044486631 cites W2099117852 @default.
• W3044486631 cites W2113407988 @default.
• W3044486631 cites W2114843025 @default.
• W3044486631 cites W2128856207 @default.
• W3044486631 cites W2136188258 @default.
• W3044486631 cites W2138207763 @default.
• W3044486631 cites W2158485828 @default.
• W3044486631 cites W2161816671 @default.
• W3044486631 cites W2169456326 @default.
• W3044486631 cites W2179438025 @default.
• W3044486631 cites W2192486833 @default.
• W3044486631 cites W225891317 @default.
• W3044486631 cites W2508189432 @default.
• W3044486631 cites W2606694952 @default.
• W3044486631 cites W2611596972 @default.
• W3044486631 cites W2737405537 @default.
• W3044486631 cites W2744685612 @default.
• W3044486631 cites W2763871199 @default.
• W3044486631 cites W2769518734 @default.
• W3044486631 cites W2770884032 @default.
• W3044486631 cites W2796183066 @default.
• W3044486631 cites W2884668039 @default.
• W3044486631 cites W2890107533 @default.
• W3044486631 cites W2895926103 @default.
• W3044486631 cites W2898709937 @default.
• W3044486631 cites W2908456822 @default.
• W3044486631 cites W2914484796 @default.
• W3044486631 cites W2936414047 @default.
• W3044486631 cites W4210599229 @default.
• W3044486631 doi "https://doi.org/10.1158/0008-5472.can-20-0069" @default.
• W3044486631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32699134" @default.
• W3044486631 hasPublicationYear "2020" @default.
• W3044486631 type Work @default.
• W3044486631 sameAs 3044486631 @default.
• W3044486631 citedByCount "90" @default.
• W3044486631 countsByYear W30444866312020 @default.
• W3044486631 countsByYear W30444866312021 @default.
• W3044486631 countsByYear W30444866312022 @default.
• W3044486631 countsByYear W30444866312023 @default.
• W3044486631 crossrefType "journal-article" @default.
• W3044486631 hasAuthorship W3044486631A5016511599 @default.
• W3044486631 hasAuthorship W3044486631A5032227105 @default.
• W3044486631 hasAuthorship W3044486631A5036241222 @default.
• W3044486631 hasAuthorship W3044486631A5052349036 @default.
• W3044486631 hasAuthorship W3044486631A5053291675 @default.
• W3044486631 hasAuthorship W3044486631A5054116239 @default.
• W3044486631 hasAuthorship W3044486631A5058734088 @default.
• W3044486631 hasAuthorship W3044486631A5059087023 @default.
• W3044486631 hasAuthorship W3044486631A5067057792 @default.
• W3044486631 hasAuthorship W3044486631A5067410182 @default.
• W3044486631 hasAuthorship W3044486631A5090020095 @default.
• W3044486631 hasBestOaLocation W30444866312 @default.
• W3044486631 hasConcept C121608353 @default.
• W3044486631 hasConcept C126322002 @default.
• W3044486631 hasConcept C142724271 @default.
• W3044486631 hasConcept C159654299 @default.
• W3044486631 hasConcept C193270364 @default.
• W3044486631 hasConcept C203014093 @default.
• W3044486631 hasConcept C204232928 @default.
• W3044486631 hasConcept C2776107976 @default.
• W3044486631 hasConcept C2776256026 @default.
• W3044486631 hasConcept C2776460901 @default.
• W3044486631 hasConcept C2778236600 @default.
• W3044486631 hasConcept C2779482015 @default.
• W3044486631 hasConcept C3020616263 @default.
• W3044486631 hasConcept C502942594 @default.
• W3044486631 hasConcept C71924100 @default.
• W3044486631 hasConcept C86803240 @default.
• W3044486631 hasConceptScore W3044486631C121608353 @default.

• next