FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044491249> ?p ?o ?g. }

• W3044491249 endingPage "758" @default.
• W3044491249 startingPage "749" @default.
• W3044491249 abstract "As a result of the COVID-19 pandemic, evidence revealed that SARS-CoV-2 infection caused taste loss at a rate higher than that of influenza. ACE2, the entry receptor of SARS-CoV-2, has been identified in the oral epithelium; however, it is unclear at what developmental stage ACE2 expression emerges and whether ACE2 is expressed in taste buds. To identify the specific developmental stage, we analyzed RNA-Seq data from embryonic and newborn mouse oral tissue. We found that robust ACE2 expression was observed in the newborn oral epithelium. In contrast, only extremely low levels, if any, of ACE2 transcripts in the embryonic stage oral tissue were found (E12.5 and E14.5). Analyses of three public scRNA-seq data sets of adult mouse tongue epithelial cells showed that receptors for various viruses were enriched in distinct clusters of tongue epithelial cells. ACE2 was enriched in a subpopulation of epithelial cells in the basal region of nongustatory filiform papillae but not in the taste papillae or taste buds. Expression of ACE2 was detected in a small proportion of type III taste cells. Our results indicate that when applied across species, nongustatory papilla epithelial cells are the prime targets for SARS-CoV-2 infection in the tongue; thus, taste loss in COVID-19 patients is likely not caused by a direct infection of SARS-CoV-2 to taste bud cells. Additionally, fetuses at different stages of development may have distinct susceptibility to SARS-CoV-2 infection." @default.
• W3044491249 created "2020-07-29" @default.
• W3044491249 creator A5000041864 @default.
• W3044491249 creator A5021532017 @default.
• W3044491249 creator A5024990162 @default.
• W3044491249 creator A5025872159 @default.
• W3044491249 creator A5083729192 @default.
• W3044491249 creator A5090838027 @default.
• W3044491249 date "2020-07-23" @default.
• W3044491249 modified "2023-10-14" @default.
• W3044491249 title "SARS-CoV-2 Receptor <i>ACE2</i> Is Enriched in a Subpopulation of Mouse Tongue Epithelial Cells in Nongustatory Papillae but Not in Taste Buds or Embryonic Oral Epithelium" @default.
• W3044491249 cites W111618758 @default.
• W3044491249 cites W1581978065 @default.
• W3044491249 cites W1966218685 @default.
• W3044491249 cites W1982215719 @default.
• W3044491249 cites W1986751342 @default.
• W3044491249 cites W1991809974 @default.
• W3044491249 cites W1996864088 @default.
• W3044491249 cites W1999574084 @default.
• W3044491249 cites W2024378963 @default.
• W3044491249 cites W2025456860 @default.
• W3044491249 cites W2027518730 @default.
• W3044491249 cites W2034780781 @default.
• W3044491249 cites W2056295620 @default.
• W3044491249 cites W2063697510 @default.
• W3044491249 cites W2066116077 @default.
• W3044491249 cites W2073213477 @default.
• W3044491249 cites W2091760668 @default.
• W3044491249 cites W2092925239 @default.
• W3044491249 cites W2093103402 @default.
• W3044491249 cites W2097933114 @default.
• W3044491249 cites W2099434983 @default.
• W3044491249 cites W2104005232 @default.
• W3044491249 cites W2109009239 @default.
• W3044491249 cites W2112785460 @default.
• W3044491249 cites W2121479815 @default.
• W3044491249 cites W2169456326 @default.
• W3044491249 cites W2179438025 @default.
• W3044491249 cites W2345007502 @default.
• W3044491249 cites W2622290652 @default.
• W3044491249 cites W2623054919 @default.
• W3044491249 cites W2742044309 @default.
• W3044491249 cites W2793094298 @default.
• W3044491249 cites W2793253965 @default.
• W3044491249 cites W2794480084 @default.
• W3044491249 cites W2894687190 @default.
• W3044491249 cites W2949771937 @default.
• W3044491249 cites W2974276026 @default.
• W3044491249 cites W3004280078 @default.
• W3044491249 cites W3007829007 @default.
• W3044491249 cites W3008295344 @default.
• W3044491249 cites W3008827533 @default.
• W3044491249 cites W3009912996 @default.
• W3044491249 cites W3010441732 @default.
• W3044491249 cites W3011093535 @default.
• W3044491249 cites W3011134208 @default.
• W3044491249 cites W3011483298 @default.
• W3044491249 cites W3012180666 @default.
• W3044491249 cites W3012421327 @default.
• W3044491249 cites W3013219143 @default.
• W3044491249 cites W3013395653 @default.
• W3044491249 cites W3013800395 @default.
• W3044491249 cites W3013882176 @default.
• W3044491249 cites W3014074888 @default.
• W3044491249 cites W3014620286 @default.
• W3044491249 cites W3014674233 @default.
• W3044491249 cites W3014922871 @default.
• W3044491249 cites W3015631092 @default.
• W3044491249 cites W3016200057 @default.
• W3044491249 cites W3016764858 @default.
• W3044491249 cites W3021809395 @default.
• W3044491249 cites W3022894063 @default.
• W3044491249 cites W3023547764 @default.
• W3044491249 cites W3024091762 @default.
• W3044491249 cites W3032695822 @default.
• W3044491249 cites W3040113773 @default.
• W3044491249 cites W3042366442 @default.
• W3044491249 cites W3046863580 @default.
• W3044491249 cites W592138015 @default.
• W3044491249 doi "https://doi.org/10.1021/acsptsci.0c00062" @default.
• W3044491249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409941" @default.
• W3044491249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32821883" @default.
• W3044491249 hasPublicationYear "2020" @default.
• W3044491249 type Work @default.
• W3044491249 sameAs 3044491249 @default.
• W3044491249 citedByCount "48" @default.
• W3044491249 countsByYear W30444912492020 @default.
• W3044491249 countsByYear W30444912492021 @default.
• W3044491249 countsByYear W30444912492022 @default.
• W3044491249 countsByYear W30444912492023 @default.
• W3044491249 crossrefType "journal-article" @default.
• W3044491249 hasAuthorship W3044491249A5000041864 @default.
• W3044491249 hasAuthorship W3044491249A5021532017 @default.
• W3044491249 hasAuthorship W3044491249A5024990162 @default.
• W3044491249 hasAuthorship W3044491249A5025872159 @default.
• W3044491249 hasAuthorship W3044491249A5083729192 @default.
• W3044491249 hasAuthorship W3044491249A5090838027 @default.
• W3044491249 hasBestOaLocation W30444912491 @default.

• next