FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044497834> ?p ?o ?g. }

• W3044497834 abstract "Abstract Recent studies have revealed that tissue macrophages are derived from yolk sac precursors or fetal liver monocytes, in addition to bone marrow monocytes. The relative contribution of these cells to the tissue macrophage pool is not fully understood, but embryo-derived cells are supposed to be more important because of their capacity to self-renew. Here, we show the presence of adult bone marrow-derived macrophages that retain self-renewing capacity. The self-renewing macrophages were readily obtained by long-term culture of mouse bone marrow cells with macrophage colony-stimulating factor (M-CSF), a key cytokine for macrophage development. They were non-tumorigenic and proliferated in the presence of M-CSF in unlimited numbers. Despite several differences from non-proliferating macrophages, they retained many features of cells of the monocytic lineage, including the differentiation into dendritic cells or osteoclasts. Among the transcription factors involved in the self-renewal of embryonic stem cells, Krüppel-like factor 2 (KLF2) was strongly upregulated upon M-CSF stimulation in the self-renewing macrophages, which was accompanied by the downregulation of MafB, a transcription factor that suppresses KLF2 expression. Indeed, knockdown of KLF2 led to cell cycle arrest and diminished cell proliferation in the self-renewing macrophages. Our new cell model would be useful to unravel differences in phenotype, function, and molecular mechanism of proliferation among self-renewing macrophages with different origins." @default.
• W3044497834 created "2020-07-29" @default.
• W3044497834 creator A5014299362 @default.
• W3044497834 creator A5024565449 @default.
• W3044497834 creator A5026180291 @default.
• W3044497834 creator A5026964697 @default.
• W3044497834 creator A5040927651 @default.
• W3044497834 creator A5055610583 @default.
• W3044497834 creator A5057259361 @default.
• W3044497834 creator A5060855417 @default.
• W3044497834 creator A5061835134 @default.
• W3044497834 creator A5062245044 @default.
• W3044497834 creator A5064949815 @default.
• W3044497834 creator A5069728941 @default.
• W3044497834 creator A5087334400 @default.
• W3044497834 date "2020-07-23" @default.
• W3044497834 modified "2023-10-09" @default.
• W3044497834 title "Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages" @default.
• W3044497834 cites W1915064499 @default.
• W3044497834 cites W1975731076 @default.
• W3044497834 cites W1984574450 @default.
• W3044497834 cites W2000308852 @default.
• W3044497834 cites W2018846024 @default.
• W3044497834 cites W2022485121 @default.
• W3044497834 cites W2025349474 @default.
• W3044497834 cites W2054540776 @default.
• W3044497834 cites W2065036402 @default.
• W3044497834 cites W2077514098 @default.
• W3044497834 cites W2096179876 @default.
• W3044497834 cites W2099443109 @default.
• W3044497834 cites W2106329796 @default.
• W3044497834 cites W2144969210 @default.
• W3044497834 cites W2153846543 @default.
• W3044497834 cites W2155766540 @default.
• W3044497834 cites W2206354307 @default.
• W3044497834 cites W2206527692 @default.
• W3044497834 cites W2242760558 @default.
• W3044497834 cites W2268619028 @default.
• W3044497834 cites W2301038687 @default.
• W3044497834 cites W2343063221 @default.
• W3044497834 cites W2443001171 @default.
• W3044497834 cites W2506892818 @default.
• W3044497834 cites W2516220433 @default.
• W3044497834 cites W2558246554 @default.
• W3044497834 cites W2611921452 @default.
• W3044497834 cites W2620588310 @default.
• W3044497834 cites W2735726751 @default.
• W3044497834 cites W2800382889 @default.
• W3044497834 cites W2808654605 @default.
• W3044497834 cites W2885203079 @default.
• W3044497834 cites W2885821180 @default.
• W3044497834 cites W2902518400 @default.
• W3044497834 cites W2904624968 @default.
• W3044497834 cites W2905503365 @default.
• W3044497834 cites W2916810724 @default.
• W3044497834 cites W2942803502 @default.
• W3044497834 cites W2967087236 @default.
• W3044497834 cites W2967574116 @default.
• W3044497834 cites W3010993131 @default.
• W3044497834 doi "https://doi.org/10.1038/s41420-020-00300-3" @default.
• W3044497834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7378060" @default.
• W3044497834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33563913" @default.
• W3044497834 hasPublicationYear "2020" @default.
• W3044497834 type Work @default.
• W3044497834 sameAs 3044497834 @default.
• W3044497834 citedByCount "14" @default.
• W3044497834 countsByYear W30444978342021 @default.
• W3044497834 countsByYear W30444978342022 @default.
• W3044497834 countsByYear W30444978342023 @default.
• W3044497834 crossrefType "journal-article" @default.
• W3044497834 hasAuthorship W3044497834A5014299362 @default.
• W3044497834 hasAuthorship W3044497834A5024565449 @default.
• W3044497834 hasAuthorship W3044497834A5026180291 @default.
• W3044497834 hasAuthorship W3044497834A5026964697 @default.
• W3044497834 hasAuthorship W3044497834A5040927651 @default.
• W3044497834 hasAuthorship W3044497834A5055610583 @default.
• W3044497834 hasAuthorship W3044497834A5057259361 @default.
• W3044497834 hasAuthorship W3044497834A5060855417 @default.
• W3044497834 hasAuthorship W3044497834A5061835134 @default.
• W3044497834 hasAuthorship W3044497834A5062245044 @default.
• W3044497834 hasAuthorship W3044497834A5064949815 @default.
• W3044497834 hasAuthorship W3044497834A5069728941 @default.
• W3044497834 hasAuthorship W3044497834A5087334400 @default.
• W3044497834 hasBestOaLocation W30444978341 @default.
• W3044497834 hasConcept C104317684 @default.
• W3044497834 hasConcept C109159458 @default.
• W3044497834 hasConcept C121608353 @default.
• W3044497834 hasConcept C145103041 @default.
• W3044497834 hasConcept C179185449 @default.
• W3044497834 hasConcept C202751555 @default.
• W3044497834 hasConcept C203014093 @default.
• W3044497834 hasConcept C2777350992 @default.
• W3044497834 hasConcept C2778690821 @default.
• W3044497834 hasConcept C2779244956 @default.
• W3044497834 hasConcept C2780007613 @default.
• W3044497834 hasConcept C28328180 @default.
• W3044497834 hasConcept C50442881 @default.
• W3044497834 hasConcept C54355233 @default.
• W3044497834 hasConcept C55493867 @default.
• W3044497834 hasConcept C55721878 @default.

• next