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- W3044506435 endingPage "1059" @default.
- W3044506435 startingPage "1047" @default.
- W3044506435 abstract "Psychological distress is associated with functional gastrointestinal disorders (FGIDs) including irritable bowel syndrome (IBS) and functional dyspepsia (FD) but only evidence from prospective longitudinal and treatment studies can indicate whether the link between FGIDs and psychological distress is causal. Emerging evidence suggests underlying biological mechanisms may explain the association of psychological distress with FGIDs.This review critically evaluates whether anxiety and/or depression and FGIDs are causally related including evidence for a temporal sequence, strength and specificity of the association, biological gradient, and biological plausibility.Accumulating evidence suggests that psychological factors are causal for symptoms in a subset of FGID patients and not explained by health care seeking behavior (brain-gut disorder). In other cases, psychological factors may arise secondary to intestinal disease (gut-brain disorder). Prospective population-based studies are needed in FGIDs other than IBS and FD to determine if a similar brain-gut and gut-brain syndrome exists. Treatment studies have not phenotyped FGIDs according to brain-gut versus gut-brain origins which may be important in understanding true treatment efficacy. Future research needs to unravel biological mechanisms that may explain the link between psychological factors and FGIDs but promising data in the area of the brain-gut-immune-microbe axis is emerging." @default.
- W3044506435 created "2020-07-29" @default.
- W3044506435 creator A5019719568 @default.
- W3044506435 creator A5022374905 @default.
- W3044506435 creator A5034890420 @default.
- W3044506435 date "2020-08-17" @default.
- W3044506435 modified "2023-09-25" @default.
- W3044506435 title "Is there a causal link between psychological disorders and functional gastrointestinal disorders?" @default.
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