FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044539736> ?p ?o ?g. }

• W3044539736 abstract "Abstract Background Both genetic and environmental factors contribute to type 2 diabetes development. We used consomic mice established from an animal type 2 diabetes model to identify susceptibility genes that contribute to type 2 diabetes development under specific environments. We previously established consomic strains (C3H-Chr 11 NSY and C3H-Chr 14 NSY ) that possess diabetogenic Chr 11 or 14 of the Nagoya-Shibata-Yasuda (NSY) mouse, an animal model of spontaneous type 2 diabetes, in the genetic background of C3H mice. To search genes contribute to type 2 diabetes under specific environment, we first investigated whether sucrose administration deteriorates type 2 diabetes-related traits in the consomic strains. We dissected loci on Chr 11 by establishing congenic strains possessing different segments of NSY-derived Chr 11 under sucrose administration. Results In C3H-Chr 11 NSY mice, sucrose administration for 10 weeks deteriorated hyperglycemia, insulin resistance, and impaired insulin secretion, which is comparable to NSY mice with sucrose. In C3H-Chr 14 NSY mice, sucrose administration induced glucose intolerance, but not insulin resistance and impaired insulin secretion. To dissect the gene(s) existing on Chr 11 for sucrose-induced type 2 diabetes, we constructed four novel congenic strains (R1, R2, R3, and R4) with different segments of NSY-derived Chr 11 in C3H mice. R2 mice showed marked glucose intolerance and impaired insulin secretion comparable to C3H-Chr 11 NSY mice. R3 and R4 mice also showed impaired insulin secretion. R4 mice showed significant decreases in white adipose tissue, which is in the opposite direction from parental C3H-Chr 11 NSY and NSY mice. None of the four congenic strains showed insulin resistance. Conclusions Genes on mouse Chr 11 could explain glucose intolerance, impaired insulin secretion, insulin resistance in NSY mice under sucrose administration. Congenic mapping with high sucrose environment localized susceptibility genes for type 2 diabetes associated with impaired insulin secretion in the middle segment (26.0–63.4 Mb) of Chr 11. Gene(s) that decrease white adipose tissue were mapped to the distal segment of Chr 11. The identification of diabetogenic gene on Chr 11 in the future study will facilitate precision medicine in type 2 diabetes by controlling specific environments in targeted subjects with susceptible genotypes." @default.
• W3044539736 created "2020-07-29" @default.
• W3044539736 creator A5001935591 @default.
• W3044539736 creator A5010502943 @default.
• W3044539736 creator A5023859731 @default.
• W3044539736 creator A5066453472 @default.
• W3044539736 creator A5070588174 @default.
• W3044539736 creator A5073950448 @default.
• W3044539736 creator A5075197576 @default.
• W3044539736 creator A5080048501 @default.
• W3044539736 date "2020-07-23" @default.
• W3044539736 modified "2023-10-09" @default.
• W3044539736 title "Type 2 diabetes susceptibility genes on mouse chromosome 11 under high sucrose environment" @default.
• W3044539736 cites W1968872919 @default.
• W3044539736 cites W1971509002 @default.
• W3044539736 cites W1985570682 @default.
• W3044539736 cites W1986742774 @default.
• W3044539736 cites W1991714900 @default.
• W3044539736 cites W1994878054 @default.
• W3044539736 cites W1998401813 @default.
• W3044539736 cites W2001596949 @default.
• W3044539736 cites W2012293809 @default.
• W3044539736 cites W2025322199 @default.
• W3044539736 cites W2033941910 @default.
• W3044539736 cites W2035961179 @default.
• W3044539736 cites W2047847153 @default.
• W3044539736 cites W2097042684 @default.
• W3044539736 cites W2107971069 @default.
• W3044539736 cites W2109862726 @default.
• W3044539736 cites W2113024584 @default.
• W3044539736 cites W2121946347 @default.
• W3044539736 cites W2122355663 @default.
• W3044539736 cites W2125974145 @default.
• W3044539736 cites W2126469682 @default.
• W3044539736 cites W2135514940 @default.
• W3044539736 cites W2144402304 @default.
• W3044539736 cites W2155351745 @default.
• W3044539736 cites W2159422401 @default.
• W3044539736 cites W2171682260 @default.
• W3044539736 cites W2978326608 @default.
• W3044539736 cites W4252731434 @default.
• W3044539736 cites W4295452167 @default.
• W3044539736 doi "https://doi.org/10.1186/s12863-020-00888-6" @default.
• W3044539736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7379357" @default.
• W3044539736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32703163" @default.
• W3044539736 hasPublicationYear "2020" @default.
• W3044539736 type Work @default.
• W3044539736 sameAs 3044539736 @default.
• W3044539736 citedByCount "2" @default.
• W3044539736 countsByYear W30445397362021 @default.
• W3044539736 countsByYear W30445397362022 @default.
• W3044539736 crossrefType "journal-article" @default.
• W3044539736 hasAuthorship W3044539736A5001935591 @default.
• W3044539736 hasAuthorship W3044539736A5010502943 @default.
• W3044539736 hasAuthorship W3044539736A5023859731 @default.
• W3044539736 hasAuthorship W3044539736A5066453472 @default.
• W3044539736 hasAuthorship W3044539736A5070588174 @default.
• W3044539736 hasAuthorship W3044539736A5073950448 @default.
• W3044539736 hasAuthorship W3044539736A5075197576 @default.
• W3044539736 hasAuthorship W3044539736A5080048501 @default.
• W3044539736 hasBestOaLocation W30445397361 @default.
• W3044539736 hasConcept C104317684 @default.
• W3044539736 hasConcept C126322002 @default.
• W3044539736 hasConcept C134018914 @default.
• W3044539736 hasConcept C171089720 @default.
• W3044539736 hasConcept C2777180221 @default.
• W3044539736 hasConcept C2777391703 @default.
• W3044539736 hasConcept C2778597767 @default.
• W3044539736 hasConcept C2779306644 @default.
• W3044539736 hasConcept C54355233 @default.
• W3044539736 hasConcept C55493867 @default.
• W3044539736 hasConcept C555293320 @default.
• W3044539736 hasConcept C71924100 @default.
• W3044539736 hasConcept C84951073 @default.
• W3044539736 hasConcept C86803240 @default.
• W3044539736 hasConceptScore W3044539736C104317684 @default.
• W3044539736 hasConceptScore W3044539736C126322002 @default.
• W3044539736 hasConceptScore W3044539736C134018914 @default.
• W3044539736 hasConceptScore W3044539736C171089720 @default.
• W3044539736 hasConceptScore W3044539736C2777180221 @default.
• W3044539736 hasConceptScore W3044539736C2777391703 @default.
• W3044539736 hasConceptScore W3044539736C2778597767 @default.
• W3044539736 hasConceptScore W3044539736C2779306644 @default.
• W3044539736 hasConceptScore W3044539736C54355233 @default.
• W3044539736 hasConceptScore W3044539736C55493867 @default.
• W3044539736 hasConceptScore W3044539736C555293320 @default.
• W3044539736 hasConceptScore W3044539736C71924100 @default.
• W3044539736 hasConceptScore W3044539736C84951073 @default.
• W3044539736 hasConceptScore W3044539736C86803240 @default.
• W3044539736 hasIssue "1" @default.
• W3044539736 hasLocation W30445397361 @default.
• W3044539736 hasLocation W30445397362 @default.
• W3044539736 hasOpenAccess W3044539736 @default.
• W3044539736 hasPrimaryLocation W30445397361 @default.
• W3044539736 hasRelatedWork W138803513 @default.
• W3044539736 hasRelatedWork W1957106181 @default.
• W3044539736 hasRelatedWork W1986132654 @default.
• W3044539736 hasRelatedWork W2010140898 @default.
• W3044539736 hasRelatedWork W2017606817 @default.
• W3044539736 hasRelatedWork W2044897248 @default.

• next