Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044541431> ?p ?o ?g. }
- W3044541431 endingPage "328" @default.
- W3044541431 startingPage "319" @default.
- W3044541431 abstract "Abstract Growing cells increase multiple biosynthetic processes in response to the high metabolic demands needed to sustain proliferation. The even higher metabolic requirements in the setting of cancer provoke proportionately greater biosynthesis. Underappreciated key aspects of this increased metabolic demand are guanine nucleotides and adaptive mechanisms to regulate their concentration. Using the malignant brain tumour, glioblastoma, as a model, we have demonstrated that one of the rate-limiting enzymes for guanosine triphosphate (GTP) synthesis, inosine monophosphate dehydrogenase-2 (IMPDH2), is increased and IMPDH2 expression is necessary for the activation of de novo GTP biosynthesis. Moreover, increased IMPDH2 enhances RNA polymerase I and III transcription directly linking GTP metabolism to both anabolic capacity as well as nucleolar enlargement historically observed as associated with cancer. In this review, we will review in detail the basis of these new discoveries and, more generally, summarize the current knowledge on the role of GTP metabolism in cancer." @default.
- W3044541431 created "2020-07-29" @default.
- W3044541431 creator A5055427979 @default.
- W3044541431 creator A5086206547 @default.
- W3044541431 date "2020-07-23" @default.
- W3044541431 modified "2023-10-12" @default.
- W3044541431 title "GTP metabolic reprogramming by IMPDH2: unlocking cancer cells’ fuelling mechanism" @default.
- W3044541431 cites W1519817796 @default.
- W3044541431 cites W1526833570 @default.
- W3044541431 cites W1553846804 @default.
- W3044541431 cites W1745549119 @default.
- W3044541431 cites W1972778166 @default.
- W3044541431 cites W1974739378 @default.
- W3044541431 cites W1979843175 @default.
- W3044541431 cites W1982635732 @default.
- W3044541431 cites W1984125778 @default.
- W3044541431 cites W1986647193 @default.
- W3044541431 cites W1989832105 @default.
- W3044541431 cites W1991252653 @default.
- W3044541431 cites W1991691204 @default.
- W3044541431 cites W1993522288 @default.
- W3044541431 cites W1993632025 @default.
- W3044541431 cites W1997922191 @default.
- W3044541431 cites W2020474748 @default.
- W3044541431 cites W2044219391 @default.
- W3044541431 cites W2044525314 @default.
- W3044541431 cites W2045074917 @default.
- W3044541431 cites W2046694248 @default.
- W3044541431 cites W2050527189 @default.
- W3044541431 cites W2058146494 @default.
- W3044541431 cites W2064295826 @default.
- W3044541431 cites W2074355406 @default.
- W3044541431 cites W2085439839 @default.
- W3044541431 cites W2087539641 @default.
- W3044541431 cites W2093139670 @default.
- W3044541431 cites W2103245284 @default.
- W3044541431 cites W2106789249 @default.
- W3044541431 cites W2112078762 @default.
- W3044541431 cites W2112738731 @default.
- W3044541431 cites W2114845709 @default.
- W3044541431 cites W2120613619 @default.
- W3044541431 cites W2120934046 @default.
- W3044541431 cites W2122289467 @default.
- W3044541431 cites W2123282517 @default.
- W3044541431 cites W2130623329 @default.
- W3044541431 cites W2132137212 @default.
- W3044541431 cites W2138170021 @default.
- W3044541431 cites W2149062070 @default.
- W3044541431 cites W2150758858 @default.
- W3044541431 cites W2152199073 @default.
- W3044541431 cites W2155610392 @default.
- W3044541431 cites W2156484461 @default.
- W3044541431 cites W2189876332 @default.
- W3044541431 cites W2230508107 @default.
- W3044541431 cites W2252570175 @default.
- W3044541431 cites W2336595145 @default.
- W3044541431 cites W2473411013 @default.
- W3044541431 cites W2602955340 @default.
- W3044541431 cites W2605119272 @default.
- W3044541431 cites W2617888483 @default.
- W3044541431 cites W2742741776 @default.
- W3044541431 cites W2749296525 @default.
- W3044541431 cites W2768065449 @default.
- W3044541431 cites W2794528932 @default.
- W3044541431 cites W2808617506 @default.
- W3044541431 cites W2810902531 @default.
- W3044541431 cites W2811343229 @default.
- W3044541431 cites W2892249667 @default.
- W3044541431 cites W2903553774 @default.
- W3044541431 cites W2909519894 @default.
- W3044541431 cites W2962903893 @default.
- W3044541431 cites W2965528058 @default.
- W3044541431 cites W2968697374 @default.
- W3044541431 cites W2973061408 @default.
- W3044541431 cites W3004101821 @default.
- W3044541431 cites W3014323330 @default.
- W3044541431 doi "https://doi.org/10.1093/jb/mvaa085" @default.
- W3044541431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7778356" @default.
- W3044541431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32702086" @default.
- W3044541431 hasPublicationYear "2020" @default.
- W3044541431 type Work @default.
- W3044541431 sameAs 3044541431 @default.
- W3044541431 citedByCount "20" @default.
- W3044541431 countsByYear W30445414312020 @default.
- W3044541431 countsByYear W30445414312021 @default.
- W3044541431 countsByYear W30445414312022 @default.
- W3044541431 countsByYear W30445414312023 @default.
- W3044541431 crossrefType "journal-article" @default.
- W3044541431 hasAuthorship W3044541431A5055427979 @default.
- W3044541431 hasAuthorship W3044541431A5086206547 @default.
- W3044541431 hasBestOaLocation W30445414311 @default.
- W3044541431 hasConcept C1008401 @default.
- W3044541431 hasConcept C104317684 @default.
- W3044541431 hasConcept C118716 @default.
- W3044541431 hasConcept C121608353 @default.
- W3044541431 hasConcept C141071460 @default.
- W3044541431 hasConcept C181199279 @default.
- W3044541431 hasConcept C184235292 @default.