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• W3044560138 endingPage "111271" @default.
• W3044560138 startingPage "111271" @default.
• W3044560138 abstract "Lipidated peptide amphiphiles exhibit high affinity for plasma cell membranes, good cell internalization and improved stability against degradation, which make them attractive as a drug delivery system. However, low drug loading capacity limits their application for drug delivery. Herein, we developed a gemini peptide amphiphile with enhanced membrane activity and endosomal escape, containing dodecanoic acid hydrophobic tails at the N-terminus, rhodamine on the pendant chain and an active targeting peptide sequence (GRGDS). The presence of rhodamine not only provides high drug loading capability due to the π-π stacking interaction between camptothecin (CPT) and rhodamine, but also promotes peptide amphiphiles to form compact spherical micelles, as well as allows for fluorescence imaging. Single-molecule total internal reflection fluorescence microscopy investigation reveals gemini peptide amphiphile has higher affinity for plasma cell membranes than single-tail peptide amphiphile. Meanwhile, better cell internalization of gemini peptide amphiphile was confirmed by flow cytometry and confocal laser scanning microscopy. Moreover, CPT-loaded gemini peptide amphiphile induced enhanced cytotoxicity in cancer cells when compared to free CPT, indicating that lipidated peptide amphiphile with π-conjugates on the pendant chain and two hydrophobic tails can serve as a highly efficient drug delivery vehicle." @default.
• W3044560138 created "2020-07-29" @default.
• W3044560138 creator A5052676364 @default.
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• W3044560138 date "2020-11-01" @default.
• W3044560138 modified "2023-10-17" @default.
• W3044560138 title "Lipidated gemini peptide amphiphiles with enhanced loading capacity and cell membrane affinity for drug delivery" @default.
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• W3044560138 doi "https://doi.org/10.1016/j.colsurfb.2020.111271" @default.
• W3044560138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32736122" @default.
• W3044560138 hasPublicationYear "2020" @default.
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