FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044606648> ?p ?o ?g. }

• W3044606648 abstract "Abstract The maintenance of sufficient but non-toxic pools of metal micronutrients is accomplished through diverse homeostasis mechanisms in fungi. Siderophores play a well-established role for iron homeostasis; however, no copper-binding analogs have been found in fungi. Here we demonstrate that in Aspergillus fumigatus isocyanides derived from the xan biosynthetic gene cluster (BGC) bind copper, impact cellular copper content, and have significant metal-dependent antimicrobial properties. xan BGC-derived isocyanides are secreted and bind copper as visualized by a chrome azurol S (CAS) assay and inductively coupled plasma-mass spectrometry (ICP-MS) analysis of A. fumigatus intracellular copper pools demonstrated a role for xan cluster metabolites in the accumulation of copper. A. fumigatus coculture with A. nidulans, Candida albicans and a variety of pathogenic bacteria establish copper-dependent antimicrobial properties of xan BGC metabolites including inhibition of laccase activity. Similarly, inhibition of Pseudomonas aeruginosa by low concentrations of the xan isocyanide xanthocillin was copper-dependent. Other metals also reduced xanthocillin’s antimicrobial properties, but less efficiently than copper. As variations of the xan BGC exist in other filamentous fungi, we suggest that xanthocillin-like natural products represent a first example for fungal small molecules that serve to maintain copper sufficiency and mediate interactions with competing microbes. Significance Metal homeostasis is an integral part of metabolism for any organism. A vast array of small molecules are already known to mediate metal homeostasis in fungi and bacteria; however, unlike their bacterial counterparts, to-date there are no known fungal small molecules that function to maintain copper homeostasis. Discovery of copper binding small molecules produced by A. fumigatus gives insight into mechanisms other than the extensively studied copper transporters or metalloproteins for how fungi can regulate copper. This has important ecological implications as securing scarce nutrients is central for fitness and survival. Additionally, studying this mechanism in A. fumigatus provides a basis for investigation of copper regulation pathways in other fungi." @default.
• W3044606648 created "2020-07-29" @default.
• W3044606648 creator A5031096328 @default.
• W3044606648 creator A5031263971 @default.
• W3044606648 creator A5031635514 @default.
• W3044606648 creator A5059606927 @default.
• W3044606648 creator A5059782749 @default.
• W3044606648 creator A5060836006 @default.
• W3044606648 creator A5078783207 @default.
• W3044606648 creator A5078846994 @default.
• W3044606648 creator A5084794955 @default.
• W3044606648 creator A5087688445 @default.
• W3044606648 date "2020-07-24" @default.
• W3044606648 modified "2023-09-25" @default.
• W3044606648 title "Dual-purpose isocyanides produced by<i>Aspergillus fumigatus</i>contribute to cellular copper sufficiency and exhibit antimicrobial activity" @default.
• W3044606648 cites W1909891465 @default.
• W3044606648 cites W1916919897 @default.
• W3044606648 cites W1984702291 @default.
• W3044606648 cites W1991058591 @default.
• W3044606648 cites W2012035078 @default.
• W3044606648 cites W2013645143 @default.
• W3044606648 cites W2027266940 @default.
• W3044606648 cites W2057333774 @default.
• W3044606648 cites W2060081344 @default.
• W3044606648 cites W2067668784 @default.
• W3044606648 cites W2088956441 @default.
• W3044606648 cites W2098438303 @default.
• W3044606648 cites W2104804511 @default.
• W3044606648 cites W2108189336 @default.
• W3044606648 cites W2113272290 @default.
• W3044606648 cites W2115978411 @default.
• W3044606648 cites W2129994851 @default.
• W3044606648 cites W2134836470 @default.
• W3044606648 cites W2138907159 @default.
• W3044606648 cites W2162379022 @default.
• W3044606648 cites W2164143799 @default.
• W3044606648 cites W2436067889 @default.
• W3044606648 cites W2520345180 @default.
• W3044606648 cites W2549976854 @default.
• W3044606648 cites W2573000119 @default.
• W3044606648 cites W2587769505 @default.
• W3044606648 cites W2611872930 @default.
• W3044606648 cites W2737678248 @default.
• W3044606648 cites W2765546586 @default.
• W3044606648 cites W2766591388 @default.
• W3044606648 cites W2767237117 @default.
• W3044606648 cites W2769504836 @default.
• W3044606648 cites W2805195007 @default.
• W3044606648 cites W2807035908 @default.
• W3044606648 cites W2885474054 @default.
• W3044606648 cites W2905340019 @default.
• W3044606648 cites W2910007588 @default.
• W3044606648 cites W2926400466 @default.
• W3044606648 cites W2941824545 @default.
• W3044606648 cites W2954175826 @default.
• W3044606648 cites W4241148009 @default.
• W3044606648 doi "https://doi.org/10.1101/2020.07.23.217810" @default.
• W3044606648 hasPublicationYear "2020" @default.
• W3044606648 type Work @default.
• W3044606648 sameAs 3044606648 @default.
• W3044606648 citedByCount "1" @default.
• W3044606648 countsByYear W30446066482021 @default.
• W3044606648 crossrefType "posted-content" @default.
• W3044606648 hasAuthorship W3044606648A5031096328 @default.
• W3044606648 hasAuthorship W3044606648A5031263971 @default.
• W3044606648 hasAuthorship W3044606648A5031635514 @default.
• W3044606648 hasAuthorship W3044606648A5059606927 @default.
• W3044606648 hasAuthorship W3044606648A5059782749 @default.
• W3044606648 hasAuthorship W3044606648A5060836006 @default.
• W3044606648 hasAuthorship W3044606648A5078783207 @default.
• W3044606648 hasAuthorship W3044606648A5078846994 @default.
• W3044606648 hasAuthorship W3044606648A5084794955 @default.
• W3044606648 hasAuthorship W3044606648A5087688445 @default.
• W3044606648 hasBestOaLocation W30446066481 @default.
• W3044606648 hasConcept C104317684 @default.
• W3044606648 hasConcept C108319773 @default.
• W3044606648 hasConcept C143065580 @default.
• W3044606648 hasConcept C178790620 @default.
• W3044606648 hasConcept C185592680 @default.
• W3044606648 hasConcept C2776923806 @default.
• W3044606648 hasConcept C2779787849 @default.
• W3044606648 hasConcept C2780917455 @default.
• W3044606648 hasConcept C4937899 @default.
• W3044606648 hasConcept C523546767 @default.
• W3044606648 hasConcept C54355233 @default.
• W3044606648 hasConcept C544778455 @default.
• W3044606648 hasConcept C55493867 @default.
• W3044606648 hasConcept C86803240 @default.
• W3044606648 hasConcept C89423630 @default.
• W3044606648 hasConceptScore W3044606648C104317684 @default.
• W3044606648 hasConceptScore W3044606648C108319773 @default.
• W3044606648 hasConceptScore W3044606648C143065580 @default.
• W3044606648 hasConceptScore W3044606648C178790620 @default.
• W3044606648 hasConceptScore W3044606648C185592680 @default.
• W3044606648 hasConceptScore W3044606648C2776923806 @default.
• W3044606648 hasConceptScore W3044606648C2779787849 @default.
• W3044606648 hasConceptScore W3044606648C2780917455 @default.
• W3044606648 hasConceptScore W3044606648C4937899 @default.
• W3044606648 hasConceptScore W3044606648C523546767 @default.
• W3044606648 hasConceptScore W3044606648C54355233 @default.

• next