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• W3044654430 abstract "Abstract DNA nanotechnology uses oligonucleotide strands to assemble molecular structures capable of performing useful operations. Here, we assembled a multifunctional prototype DNA nanodevice, DOCTR, that recognizes a single nucleotide mutation in a cancer marker RNA. The nanodevice then cuts out a signature sequence and uses it as an activator for a “therapeutic” function, namely, the cleavage of another RNA sequence. The proposed design is a prototype for a gene therapy DNA machine that cleaves a housekeeping gene only in the presence of a cancer‐causing point mutation and suppresses cancer cells exclusively with minimal side effects to normal cells." @default.
• W3044654430 created "2020-07-29" @default.
• W3044654430 creator A5035892020 @default.
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• W3044654430 date "2020-09-07" @default.
• W3044654430 modified "2023-10-18" @default.
• W3044654430 title "Cut and Paste for Cancer Treatment: A DNA Nanodevice that Cuts Out an RNA Marker Sequence to Activate a Therapeutic Function" @default.
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• W3044654430 doi "https://doi.org/10.1002/anie.202006384" @default.
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