FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044655057> ?p ?o ?g. }

• W3044655057 abstract "Abstract The intrinsic lymphatic contractile activity is necessary for proper lymph transport. Mesenteric lymphatic vessels from high-fructose diet-induced metabolic syndrome (MetSyn) rats exhibited impairments in its intrinsic phasic contractile activity; however, the molecular mechanisms responsible for the weaker lymphatic pumping activity in MetSyn conditions are unknown. Several metabolic disease models have shown that dysregulation of sarcoplasmic reticulum Ca 2+ ATPase (SERCA) pump is one of the key determinants of the phenotypes seen in various muscle tissues. Hence, we hypothesized that a decrease in SERCA pump expression and/or activity in lymphatic muscle influences the diminished lymphatic vessel contractions in MetSyn animals. Results demonstrated that SERCA inhibitor, thapsigargin, significantly reduced lymphatic phasic contractile frequency and amplitude in control vessels, whereas, the reduced MetSyn lymphatic contractile activity was not further diminished by thapsigargin. While SERCA2a expression was significantly decreased in MetSyn lymphatic vessels, myosin light chain 20, MLC 20 phosphorylation was increased in these vessels. Additionally, insulin resistant lymphatic muscle cells exhibited elevated intracellular calcium and decreased SERCA2a expression and activity. The SERCA activator, CDN 1163 partially restored lymphatic contractile activity in MetSyn lymphatic vessel by increasing phasic contractile frequency. Thus, our data provide the first evidence that SERCA2a modulates the lymphatic pumping activity by regulating phasic contractile amplitude and frequency, but not the lymphatic tone. Diminished lymphatic contractile activity in the vessels from the MetSyn animal is associated with the decreased SERCA2a expression and impaired SERCA2 activity in lymphatic muscle." @default.
• W3044655057 created "2020-07-29" @default.
• W3044655057 creator A5031029828 @default.
• W3044655057 creator A5064167770 @default.
• W3044655057 creator A5077699343 @default.
• W3044655057 date "2020-07-23" @default.
• W3044655057 modified "2023-09-29" @default.
• W3044655057 title "Roles of sarcoplasmic reticulum Ca2+ ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model" @default.
• W3044655057 cites W1509053484 @default.
• W3044655057 cites W1531642080 @default.
• W3044655057 cites W1533913166 @default.
• W3044655057 cites W1546499360 @default.
• W3044655057 cites W184935174 @default.
• W3044655057 cites W1968237864 @default.
• W3044655057 cites W1970920203 @default.
• W3044655057 cites W1976841933 @default.
• W3044655057 cites W1977551186 @default.
• W3044655057 cites W1990634815 @default.
• W3044655057 cites W1991973105 @default.
• W3044655057 cites W1992485823 @default.
• W3044655057 cites W1997245611 @default.
• W3044655057 cites W2001017575 @default.
• W3044655057 cites W2005845695 @default.
• W3044655057 cites W2008523196 @default.
• W3044655057 cites W2017456438 @default.
• W3044655057 cites W2031337962 @default.
• W3044655057 cites W2042970659 @default.
• W3044655057 cites W2043863706 @default.
• W3044655057 cites W2044178530 @default.
• W3044655057 cites W2058368576 @default.
• W3044655057 cites W2058920539 @default.
• W3044655057 cites W2059447983 @default.
• W3044655057 cites W2067146747 @default.
• W3044655057 cites W2067150213 @default.
• W3044655057 cites W2074610906 @default.
• W3044655057 cites W2075719343 @default.
• W3044655057 cites W2081562096 @default.
• W3044655057 cites W2082295516 @default.
• W3044655057 cites W2085220756 @default.
• W3044655057 cites W2091993254 @default.
• W3044655057 cites W2098505754 @default.
• W3044655057 cites W2098612318 @default.
• W3044655057 cites W2099540110 @default.
• W3044655057 cites W2101904915 @default.
• W3044655057 cites W2104333499 @default.
• W3044655057 cites W2104338804 @default.
• W3044655057 cites W2104532828 @default.
• W3044655057 cites W2123975199 @default.
• W3044655057 cites W2124034869 @default.
• W3044655057 cites W2124073510 @default.
• W3044655057 cites W2135273977 @default.
• W3044655057 cites W2138742704 @default.
• W3044655057 cites W2140660269 @default.
• W3044655057 cites W2141260882 @default.
• W3044655057 cites W2143622107 @default.
• W3044655057 cites W2150803463 @default.
• W3044655057 cites W2152066673 @default.
• W3044655057 cites W2153058258 @default.
• W3044655057 cites W2154768987 @default.
• W3044655057 cites W2155654101 @default.
• W3044655057 cites W2156314083 @default.
• W3044655057 cites W2166993863 @default.
• W3044655057 cites W2167060203 @default.
• W3044655057 cites W2167924679 @default.
• W3044655057 cites W2187660422 @default.
• W3044655057 cites W2219311098 @default.
• W3044655057 cites W2275208215 @default.
• W3044655057 cites W2302483317 @default.
• W3044655057 cites W2318859337 @default.
• W3044655057 cites W2320681237 @default.
• W3044655057 cites W2330854548 @default.
• W3044655057 cites W2337872948 @default.
• W3044655057 cites W2395939742 @default.
• W3044655057 cites W2416609191 @default.
• W3044655057 cites W2417507144 @default.
• W3044655057 cites W2516155714 @default.
• W3044655057 cites W2516643029 @default.
• W3044655057 cites W2557361863 @default.
• W3044655057 cites W2580792129 @default.
• W3044655057 cites W2732109967 @default.
• W3044655057 cites W2781506428 @default.
• W3044655057 cites W2921585179 @default.
• W3044655057 cites W2955855102 @default.
• W3044655057 cites W2999220255 @default.
• W3044655057 cites W4233111301 @default.
• W3044655057 cites W4294748274 @default.
• W3044655057 cites W97375708 @default.
• W3044655057 doi "https://doi.org/10.1038/s41598-020-69196-4" @default.
• W3044655057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7378550" @default.
• W3044655057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32704072" @default.
• W3044655057 hasPublicationYear "2020" @default.
• W3044655057 type Work @default.
• W3044655057 sameAs 3044655057 @default.
• W3044655057 citedByCount "11" @default.
• W3044655057 countsByYear W30446550572021 @default.
• W3044655057 countsByYear W30446550572022 @default.
• W3044655057 countsByYear W30446550572023 @default.
• W3044655057 crossrefType "journal-article" @default.
• W3044655057 hasAuthorship W3044655057A5031029828 @default.
• W3044655057 hasAuthorship W3044655057A5064167770 @default.

• next