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- W3044659504 abstract "A better understanding of the key molecules/pathways underlying the pathophysiology of depression and schizophrenia may contribute to novel therapeutic strategies. In this review, we have discussed the recent developments on the role of inflammatory pathways in the pathogenesis of depression and schizophrenia.Inflammation is an innate immune response that can be triggered by various factors, including pathogens, stress and injury. Under normal conditions, the inflammatory responses quiet after pathogen clearance and tissue repair. However, abnormal long-term or chronic inflammation can lead to damaging effects. Accumulating evidence suggest that dysregulated inflammation is linked to the pathogenesis of neuropsychiatric disorders. In this review, we have discussed the roles of complement system, infiltration of peripheral immune cells into the central nervous system (CNS), the gut-brain axis, and the kynurenine pathway in depression and schizophrenia.There is a large body of compelling evidence on the role of inflammatory pathways in depression and schizophrenia. Although most of these findings show their roles in the pathophysiology of the above disorders, additional studies are warranted to investigate the therapeutic potential of various immune signaling targets discussed in this article." @default.
- W3044659504 created "2020-07-29" @default.
- W3044659504 creator A5009914294 @default.
- W3044659504 creator A5054433535 @default.
- W3044659504 creator A5085155459 @default.
- W3044659504 date "2020-07-26" @default.
- W3044659504 modified "2023-10-17" @default.
- W3044659504 title "Inflammatory Pathways in Psychiatric Disorders: the Case of Schizophrenia and Depression" @default.
- W3044659504 cites W1456373634 @default.
- W3044659504 cites W1486365785 @default.
- W3044659504 cites W1499593166 @default.
- W3044659504 cites W1514423159 @default.
- W3044659504 cites W1574388573 @default.
- W3044659504 cites W1592101872 @default.
- W3044659504 cites W1967029543 @default.
- W3044659504 cites W1970321853 @default.
- W3044659504 cites W1971102239 @default.
- W3044659504 cites W1973172818 @default.
- W3044659504 cites W1974103256 @default.
- W3044659504 cites W1978414529 @default.
- W3044659504 cites W1981907384 @default.
- W3044659504 cites W1991604982 @default.
- W3044659504 cites W2004243143 @default.
- W3044659504 cites W2004863282 @default.
- W3044659504 cites W2014510682 @default.
- W3044659504 cites W2015725986 @default.
- W3044659504 cites W2016292245 @default.
- W3044659504 cites W2025980618 @default.
- W3044659504 cites W2031441917 @default.
- W3044659504 cites W2041439089 @default.
- W3044659504 cites W2048876068 @default.
- W3044659504 cites W2051269298 @default.
- W3044659504 cites W2059032097 @default.
- W3044659504 cites W2061794524 @default.
- W3044659504 cites W2063393311 @default.
- W3044659504 cites W2066176460 @default.
- W3044659504 cites W2081941716 @default.
- W3044659504 cites W2083054478 @default.
- W3044659504 cites W2090984824 @default.
- W3044659504 cites W2106172174 @default.
- W3044659504 cites W2135266046 @default.
- W3044659504 cites W2137823415 @default.
- W3044659504 cites W2139194458 @default.
- W3044659504 cites W2151702367 @default.
- W3044659504 cites W2160768423 @default.
- W3044659504 cites W2161527093 @default.
- W3044659504 cites W2164179897 @default.
- W3044659504 cites W2166429487 @default.
- W3044659504 cites W2176147150 @default.
- W3044659504 cites W2255138985 @default.
- W3044659504 cites W2273585977 @default.
- W3044659504 cites W2277411172 @default.
- W3044659504 cites W2277471280 @default.
- W3044659504 cites W2337492846 @default.
- W3044659504 cites W2396821322 @default.
- W3044659504 cites W2397045879 @default.
- W3044659504 cites W2412905604 @default.
- W3044659504 cites W2417262312 @default.
- W3044659504 cites W2460079419 @default.
- W3044659504 cites W2474892006 @default.
- W3044659504 cites W2605062075 @default.
- W3044659504 cites W2618788509 @default.
- W3044659504 cites W2619933220 @default.
- W3044659504 cites W2736208466 @default.
- W3044659504 cites W2741302852 @default.
- W3044659504 cites W2744068958 @default.
- W3044659504 cites W2755585885 @default.
- W3044659504 cites W2763033155 @default.
- W3044659504 cites W2766157606 @default.
- W3044659504 cites W2767440265 @default.
- W3044659504 cites W2768365173 @default.
- W3044659504 cites W2770886817 @default.
- W3044659504 cites W2782231190 @default.
- W3044659504 cites W2785607628 @default.
- W3044659504 cites W2789312859 @default.
- W3044659504 cites W2792051545 @default.
- W3044659504 cites W2802032956 @default.
- W3044659504 cites W2806345334 @default.
- W3044659504 cites W2810906666 @default.
- W3044659504 cites W2883669107 @default.
- W3044659504 cites W2885929360 @default.
- W3044659504 cites W2891409559 @default.
- W3044659504 cites W2897267201 @default.
- W3044659504 cites W2901341981 @default.
- W3044659504 cites W2902277044 @default.
- W3044659504 cites W2902372813 @default.
- W3044659504 cites W2909208688 @default.
- W3044659504 cites W2911706821 @default.
- W3044659504 cites W2912242406 @default.
- W3044659504 cites W2929017669 @default.
- W3044659504 cites W2939948226 @default.
- W3044659504 cites W2953864347 @default.
- W3044659504 cites W2964272932 @default.
- W3044659504 cites W2966352467 @default.
- W3044659504 cites W2969235541 @default.
- W3044659504 cites W2969651572 @default.
- W3044659504 cites W2970478205 @default.
- W3044659504 cites W2970623573 @default.